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Studies on hyaluronidase, chondroitin sulphatase, proteinase and phospholipase secreted by Candida species
(Blackwell Wissenschafts Verlag Gmbh, 1996-05-01)
We studied the ability of different Candida species to produce,at the same time, hyaluronidase, chondroitin sulphatase, proteinase, and phospholipase to assess whether they could be related to Candida pathogenicity. Only ...
Proteinase activity regulation by glycosaminoglycans
(Associação Brasileira de Divulgação Científica, 2002-02-01)
There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and ...
INHIBITORS of the MAJOR CYSTEINYL PROTEINASE (GP57/51) IMPAIR HOST-CELL INVASION and ARREST the INTRACELLULAR DEVELOPMENT of TRYPANOSOMA-CRUZI INVITRO
(Elsevier B.V., 1992-06-01)
Peptidyl diazomethane (PDAM) derivatives, a class of irreversible inhibitors for cysteine proteinase, were screened for the ability to impair Trypanosoma cruzi invasion and intracellular development in primary cultures of ...
Proteinase inhibitors in Brazilian leguminosae
(Instituto Oswaldo Cruz, Ministério da Saúde, 1991-01-01)
Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting ...
Molecular model for the binary complex of uropepsin and pepstatin
(Academic Press Inc., 2001-09-14)
The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in ...
Poliovirus 3C proteinase inhibition by organotelluranes
(Walter de Gruyter & Co, 2011-04-01)
The 3C proteinase, essential for human poliovirus (PV) replication, has unique characteristics as its three-dimensional structure resembles chymotrypsin, but its catalytic nucleophile is a cysteine SH group rather than the ...
Purification and preliminary characterization of a plasma kallikrein inhibitor isolated from sea hares Aplysia dactylomela Rang, 1828
(Elsevier B.V., 2004-02-01)
An inhibitor active against pancreatic trypsin was found in the crude extract from the sea hares Aplysia dactylomela Rang, 1828. A stronger inhibitory activity against human plasma kallikrein was detectable after treating ...
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
(2005-02-01)
Proteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, ...
Partial protective responses induced by a recombinant cysteine proteinase from Leishmania (Leishmania) amazonensis in a murine model of cutaneous leishmaniasis
(Elsevier B.V., 2010-02-01)
A 500 bp fragment encoding an isoform of cysteine proteinase from Leishmania (Leishmania) amazonensis was subcloned and expressed in the pHis vector, resulting in a recombinant protein of 24 kDa, rLacys24. in Western blots ...
Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
(Elsevier B.V., 2001-09-03)
We have isolated and purified two cysteine proteinases of molecular weights 25 and 26 kDa, secreted by Fasciola hepatica adult worm. Their 15 N-terminal residues were found to be identical to those of earlier described ...