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Free radicals derived from γ-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals
(Elsevier, 2020)
The enhanced green fluorescent protein (eGFP) is one of the most employed variants of fluorescent proteins.
Nonetheless little is known about the oxidative modifications that this protein can undergo in the cellular ...
3-Hydroxykynurenine bound to eye lens proteins induces oxidative modifications in crystalline proteins through a type I photosensitizing mechanism
(Elsevier Inc., 2019)
Photosensitized reactions mediated by endogenous chromophores have been associated with the etiology of age-related cataract disease. Endogenous chromophores such as 3-hydroxykynurenine (3OHKN) can be found in both free ...
Chemical Modification of Lysozyme, Glucose 6‑Phosphate Dehydrogenase, and Bovine Eye Lens Proteins Induced by Peroxyl Radicals: Role of Oxidizable Amino Acid Residues
(2013)
Chemical and structural alterations to lysozyme
(LYSO), glucose 6-phosphate dehydrogenase (G6PD), and
bovine eye lens proteins (BLP) promoted by peroxyl radicals
generated by the thermal decomposition of 2,2′-azobis(2 ...
The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
(Elsevier Inc., 2017)
© 2017 Elsevier Inc. FtsZ (filamenting temperature-sensitive mutant Z) is a key protein in bacteria cell division. The wild-type Escherichia coli FtsZ sequence (FtsZwt) contains three tyrosine (Tyr, Y) and sixteen methionine ...
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside
(Elsevier, 2018-04-25)
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
Characterization of 14-3‑3 Isoforms Expressed in the Echinococcus granulosus Pathogenic Larval Stage
(American Chemical Society, 2015)
The 14-3-3 protein family of eukaryotic
regulators was studied in Echinococcus granulosus, the causative
agent of cystic hydatid disease. These proteins mediate
important cellular processes in eukaryotes and are ...
Structure of rotavirus particle: Interaction of the inner capsid protein VP6 with the core polypeptide VP3
(1994)
The structural relationship between VP6 (inner capsid polypeptide) and the viral core was studied using chemical cross-linking with dithiobis(succinimidyl propionate). Crosslinked single shelled and reconstituted rotavirus ...
Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: Role of oxidizable amino acid residues
(2013)
Chemical and structural alterations to lysozyme (LYSO), glucose 6-phosphate dehydrogenase (G6PD), and bovine eye lens proteins (BLP) promoted by peroxyl radicals generated by the thermal decomposition of 2,2′-azobis(2- ...
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model
(Nature Publishing Group, 2017)
Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe
(Blackwell Publishing Ltd, 2017)
© 2017 Federation of European Biochemical Societies In Schizosaccharomyces pombe, ribosomal protein gene (RPG) promoters contain a TATA box analog, the HomolD box, which is bound by the Rrn7 protein. Despite the importance ...