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Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype
(Elsevier Inc., 2018)
© 2017 Elsevier Inc. To understand the impact of exposure to steroids in the early step of ovary development (a stage occurring in uterus in humans), we studied neonatal exposure to estradiol valerate (EV) in rats regarding ...
Insulin resistance and polycystic ovary syndrome through life
(2012)
The heterogeneity of Polycystic Ovary Syndrome (PCOS) emphasizes the need for a consensual review of the data concerning its diagnosis and treatment and for determination of the relationship between the development of PCOS ...
In vivo β-adrenergic blockade by propranolol prevents isoproterenol-induced polycystic ovary in adult rats
(2012)
Increasing evidence in animal models and in humans shows that sympathetic nerve activity controls ovarian androgen biosynthesis and follicular development. Thus, sympathetic nerve activity participates in the follicular ...
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
(Karger AG, 2015)
Background/Aims: The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological ...
In vivo blockade of ovarian sympathetic activity by neosaxitoxin prevents polycystic ovary in rats
(Biocientífica, 2020)
A high sympathetic tone is observed in the development and maintenance of the polycystic ovary (PCO)
phenotype in rats. Neosaxitoxin (NeoSTX) specifically blocks neuronal voltage-dependent Na+
channels, and we studied ...
Expression of melanocortin receptors mRNA, and direct effects of ACTH on steroid secretion in the bovine ovary
(Elsevier, 2011)
Melanocortin receptors (MCRs) are involved in physiological responses to ACTH, as well as to -, - and -melanocytestimulating
hormone ( -, - and -MSH). Their expression has previously been analyzed in various bovine ...
Nerve growth factor: a dual activator of noradrenergic and cholinergic systems of the rat ovary
(Frontiers Media, 2021)
The functioning of the ovary is influenced by the autonomic system (sympathetic and
cholinergic intraovarian system) which contributes to the regulation of steroid secretion,
follicular development, and ovulation. There ...
Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat
(ENDOCRINE SOC, 2000-03)
A single injection of estradiol valerate induces a form of cystic ovary resembling some aspects of the human polycystic ovarian syndrome. Preceding the development of follicular cysts, there is an increase in intraovarian ...
Release of norepinephrine from human ovary
(2001)
We investigated the possibility that norepinephrine from the human ovary is released after nerve stimulation and that this neurotransmitter is coupled to a steroidogenic response. Biologically significant levels of both ...
Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats
(2012)
Objective: To investigate the developmental window in which E2 exposure produces irreversible changes in ovarian function resulting in polycystic ovary. Design: Basic experimental study. Setting: University animal laboratory. ...