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Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosisAlteraciones morfológicas en las mitocondrias en la piel de enfermos con esclerosis lateral amiotrófica esporádica
(Academia Brasileira de Neurologia, 2012-01)
Mitochondrial dysfunction has been reported in the central nervous system, hepatocytes and peripheral blood lymphocytes from patients with sporadic amyotrophic lateral sclerosis (SALS). However, the status of skin mitochondria ...
Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line
(Endocrine Society, 2012-07)
Although the role of arachidonic acid (AA) in angiotensin II (ANG II)- and potassium-stimulated steroid production in zona glomerulosa cells is well documented, the mechanism responsible for AA release is not fully described. ...
A New Class of Thioredoxin‐Related Protein Able to Bind Iron-Sulfur Clusters
(Mary Ann Liebert, 2015-09)
AIMS:Members of the thioredoxin (Trx) protein family participate mainly in redox pathways and have not been associated with Fe/S binding, in contrast to some closely related glutaredoxins (Grxs). Cestode parasites possess ...
Smaug membraneless organelles regulate mitochondrial function
(Cold Spring Harbor Laboratory, 2020-07-31)
Smaug is a conserved translational repressor that recognizes specific RNA motifs in a large number of mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs have been shown to form membraneless ...
Fruit metabolic and transcriptional programs differentiate among Andean tomato (Solanum lycopersicum L.) accessions
(Springer, 2019-09-16)
Traditional landraces or “criollo” tomatoes (Solanum lycopersicum L.) from Andean areas of Argentina, selected for their fruit quality, were analysed in this study. We explored the metabolome and transcriptome of the ripe ...
Shock hemorrágico: óxido nítrico en ratas anestesiadas y no anestesiadas
(Sociedad Argentina de Cardiología, 2009-12)
Antecedentes: En un trabajo previo mostramos que el estado hipovolémico inducido por una pérdida aguda de sangre se acompaña de una activación dinámica, heterogénea y dependiente del tiempo de la óxido nítrico sintetasa ...
αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
(Nature, 2017-07)
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role. However, the mechanisms by which αSyn and its disease-associated ...
La redistribución dinámica mitocondria-núcleo de la inmunofilina fkbp51 es regulada por pka para modular la expresión de genes durante el proceso de adipogénesisThe dynamic mitochondria-nuclear redistribution of FKBP51 during the process of adipocyte differentiation is regulated by PKA
(Medicina (Buenos Aires), 2013-11)
Los glucocorticoides tienen un papel central en la adipogénesis, por su unión al receptor RG cito-plasmático formando parte de un heterocomplejo también integrado por una inmunofilina (INM) de alto peso molecular, FKBP51 ...
Taking advantage og organelle genomes in plant breeding: an integrated approach = Aprovechando los genomas de las organelas en el mejoramiento genético de plantas: un enfoque integrado
(Sociedad Argentina de Genética, 2019-07)
Plant cells carry their genetic information in three compartments: the nucleus, the plastids and the mitochondria. In last years, next-generation sequencing has allowed the development of genomic databases, which are ...