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Insulin receptor membrane retention by a traceable chimeric mutant
(Biomed Central, 2013-06)
Background: The insulin receptor (IR) regulates glucose homeostasis, cell growth and differentiation. It has been hypothesized that the specific signaling characteristics of IR are in part determined by ligand-receptor ...
The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver
(Elsevier Ireland, 2003-07)
The in vivo status of the proximal components of the insulin signaling system was investigated in skeletal muscle of Ames (Prop1 df/Prop1df) dwarf mice. The insulin-stimulated phosphorylation of the insulin receptor (IR) ...
Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
(Biomed Central, 2013-03-11)
Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity. The insulin receptor (IR) binds insulin ...
Retraction: Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B
(Company of Biologists, 2012-07)
The authors wish to retract this paper after it has come to their attention that the constructs of insulin receptor (IR) isoform A were of isoform B. This was discovered when the constructs were subcloned into retroviral ...
The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7)
(Elsevier Science, 2012-08)
Angiotensin (Ang)-(1-7) stimulates proteins belonging to the insulin signaling pathway and ameliorates the Ang II negative effects at this level. However, up to date, receptors involved and mechanisms behind these observations ...
Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B
(Company of Biologists, 2011-03)
Insulin signaling comprises a complex cascade of events, playing a key role in the regulation of glucose metabolism and cellular growth. Impaired response to insulin is the hallmark of diabetes, whereas upregulated insulin ...
Type A Insulin Resistance Syndrome- Novel insulin receptor gene mutation and familiar phenotypic variability
(Peertechz Publications, 2019-06)
Type A Insulin Resistance Syndrome is due to heterozygous mutations in the insulin receptor (INSR) gene or its signaling pathway. We present a premenarcheal 14 year-old girl with normal BMI, severe hirsutism, acanthosis ...
Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity
(Elsevier Ireland, 2019-12)
The renin-angiotensin system modulates insulin action. Pharmacological stimulation of angiotensin type 2 receptor (AT2R) was shown to have beneficial metabolic effects in various animal models of insulin resistance and ...
Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors
(Wiley Blackwell Publishing, Inc, 2009-09-10)
The insulin receptor (ir) and ir signaling proteins are widely distributed throughout the cns. ir signaling provides a trophic signal for transformed retinal neurons in culture and we recently reported that deletion of ir ...
Recruitment of GABAA receptors and fearfulness in chicks: Modulation by systemic insulin and/or epinephrine
(Elsevier Inc, 2013-01)
One-day-old chicks were individually assessed on their latency to peck pebbles, and categorized as low latency (LL) or high latency (HL) according to fear. Interactions between acute stress and systemic insulin and epinephrine ...