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Naltrexone effects on insulin sensitivity and insulin secretion in hyperandrogenic women
(1998)
A total of 12 women (24.2 ± 1.6 years old, BMI 36.7 ± 1.5 Kg/m2) with hyperandrogenism (HA) and with normal glucose tolerance test were studied to evaluate the involvement of endogenous opioids in the pathophysiology of ...
Calcium signaling in insulin action on striated muscle
(Churchill Livingstone, 2014)
© 2014 Elsevier Ltd. Striated muscles (skeletal and cardiac) are major physiological targets of insulin and this hormone triggers complex signaling pathways regulating cell growth and energy metabolism. Insulin increases ...
Glucocorticoid receptor β overexpression has agonist-independent insulin-mimetic effects on HepG2 glucose metabolism
(MDPI, 2022)
Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GR alpha and GR beta. ...
Relationship between insulin sensitivity and IGF-I sensitivity in low birth weight prepubertal children
(2008)
Background: Insulin-like growth factor-I (IGF-I) and insulin are structurally related proteins with similar receptors and signal transduction systems. Aim: We postulate that some low birth weight (LBW) children may have ...
Domeless receptor loss in fat body tissue reverts insulin resistance induced by a high-sugar diet in Drosophila melanogaster
(Nature, 2021)
Insulin resistance is a hallmark of type 2 diabetes resulting from the confluence of several factors, including genetic susceptibility, inflammation, and diet. Under this pathophysiological condition, the dysfunction of ...
Multiple mechanisms of regulation of estrogen action in the rat uterus: Effects of insulin
(1983)
Eosinophils appear in the rat uterus in the presence of estrogen. The level of these cells in the uterus depends on the number of blood eosinophils. Insulin is an eosinopenic hormone in the blood and, therefore, could ...
IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children
(2009)
Background/Aims: The GH-IGF-I axis plays an important role on pre/postnatal growth in humans, and IGF-I regulates cell proliferation, differentiation, and metabolic homeostasis. The adipose tissue has an important function ...
The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice
(American Physiological Society, 2015)
Insulin stimulates glucose uptake in adult skeletal muscle by promoting the translocation of GLUT4 glucose transporters to the transverse tubule (T-tubule) membranes, which have particularly high cholesterol levels. We ...
IGF-I and insulin induce different intracellular calcium signals in skeletal muscle cells
(SOC ENDOCRINOLOGY, 2004-08)
We studied the effect of IGF-I and insulin on intracellular Ca2+ in primary cultured myotubes. IGF-I induced a fast and transient Ca2+ increase, measured as fluo-3 fluorescence. This response was blocked by both genistein ...
Fluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 β-cells
(Georg Thieme Verlag, 2015)
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York. Introduction: Pancreatic β-cells synthetize and store Serotonin (5-Hydroxytriptamine, 5HT) which is co-released with insulin. It has been proposed that ...