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Differential steroidogenic response of human luteal cell subpopulations
(Oxford University, 1996)
The differentia] capacity for steroid synthesis of human
luteal cell subpopulations was investigated in a well defined
cell culture system. Corpora lutea were enzymatically
dissociated, and the two cell types were ...
Activation of Cl Channels by Human Chorionic Gonadotropin in Luteinized Granulosa Cells of the Human Ovary Modulates Progesterone Biosynthesis
(ENDOCRINE SOC, 2008-09)
Chloride permeability pathways and progesterone (P4) secretion
elicited by human chorionic gonadotropin (hCG) in
human granulosa cells were studied by electrophysiological
techniques and single-cell volume, membrane ...
Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells
(NATL ACAD SCIENCES, 2012-12-04)
Despite a high degree of conservation, subtle but important differences exist between the CD1d antigen presentation pathways of humans and mice. These differences may account for the minimal success of natural killer T ...
A flow cytometric procedure for the quantification of cell adhesion in complex mixtures of cells
(1999)
We present a simple non-radioactive cytometry-based assay that permits the simultaneous quantitation of cell adhesion of distinct subsets of cells contained in a mixture without any previous fractionation. The procedure ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Effect of desialylated human chorionic gonadotropin (hCG) on the bioactivity of rat Leydig cells
(1998)
Human chorionic gonadotropin is a glycoprotein hormone that, like LH, stimulates steroidogenesis in gonadal cells. Using a desialylation process, 95 per cent of the sialic acid residues from an intact standard hCG molecule ...
The increased expression of receptor activator of nuclear-κB ligand (RANKL) of multiple myeloma bone marrow stromal cells is inhibited by the bisphosphonate ibandronate
(2010)
The receptor activator of nuclear factor-kappaB ligand (RANKL) and interleukin-1beta are osteoclast activating factors which are abnormally expressed in bone marrow stromal cells and plasma cells of multiple myeloma patients. ...
Amide-Linked C4″-saccharide modification of krn7000 provides potent stimulation of human invariant NKT cells and anti-tumor immunity in a humanized mouse model
(American Chemical Society, 2020)
Activation of invariant natural killer T (iNKT) cells
by α-galactosylceramides (α-GalCers) stimulates strong immune
responses and potent anti-tumor immunity. Numerous modifications
of the glycolipid structure have been ...
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
(Nature Publishing Group, 2016)
Certain types of glycolipids have been found to have remarkable immunomodulatory properties as a result of their ability to activate specific T lymphocyte populations with an extremely wide range of immune effector properties. ...
The compound 14-keto stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells
(1998)
We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...