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Diagnosis of pulmonary embolism in patients with acute exacerbations of chronic obstructive pulmonary disease: a cross-sectional study
(Wiley Blackwell Publishing, Inc, 2020-12)
Introduction: Pulmonary embolism (PE) remains a frequent complication in patients with chronic obstructive pulmonary disease (COPD). It is unclear that the extent to which the traditional risk stratifying scores for PE are ...
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries
(Mosby-Elsevier, 2019-04)
Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung ...
MicroRNA dysregulation in pulmonary arteries from chronic obstructive pulmonary disease: Relationships with vascular remodeling
(American Thoracic Society, 2018-10)
Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are ...
Gene expression profile of angiogenic factors in pulmonary arteries in COPD: Relationship with vascular remodeling
(American Physiological Society, 2016-04)
Pulmonary vessel remodeling in chronic obstructive pulmonary disease (COPD) involves changes in smooth muscle cell proliferation, which are highly dependent on the coordinated interaction of angiogenicrelated growth factors. ...
Optimization of Ciprofloxacin Hydrochloride Spray-Dried Microparticles for Pulmonary Delivery Using Design of Experiments
(Springer, 2018-10)
Ciprofloxacin is a broad-spectrum antibiotic for treatment of pulmonary diseases such as chronic obstructive pulmonary disease and cystic fibrosis. The purpose of this work was to rationally study the spray drying of ...
Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up
(B M J Publishing Group, 2015-02)
BACKGROUND: Postinfectious bronchiolitis obliterans (BO) is a chronic respiratory disease that usually follows a severe adenovirus infection. OBJECTIVE: To determine the evolution of pulmonary function and clinical outcome ...
N-acetyl cysteine reverts the proinflammatory state induced by cigarette smoke extract in lung Calu-3 cells
(Elsevier, 2018-06)
Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are lethal pulmonary diseases. Cigarette consumption is the main cause for development of COPD, while CF is produced by mutations in the CFTR gene. ...
Cigarette smoke modifies and inactivates SPLUNC1, leading to airway dehydration
(Federation of American Societies for Experimental Biology, 2018-12)
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. Cigarette smoke (CS) exposure, a major cause of COPD, dysregulates airway epithelial ion transport and diminishes airway ...
SLPI (secretory leukocyte peptidase inhibitor)
(University Hospital of Poitiers, 2015-08)
Secretory Leukocyte Peptidase Inhibitor (SLPI) functionality in health and disease: Secretory Leukocyte Peptidase Inhibitor (SLPI) is a serine protease inhibitor of cathepsin G, trypsin and chymotrypsin, but primarily ...
Evidence of eosinophil extracellular trap cell death in copd: Does it represent the trigger that switches on the disease?
(Dove Press, 2017-03)
In spite of the numerous studies on chronic obstructive pulmonary disease (COPD), the cellular and molecular basis of the disease’s development remain unclear. Neutrophils and eosinophils are known to be key players in ...