Now showing items 1-10 of 64
Chromosomal aberrations involving telomeres and interstitial telomeric sequences
(Oxford University Press, 2012-01)
Telomeres are specialised nucleoproteic complexes localised at the physical ends of linear eukaryotic chromosomes that maintain their stability and integrity. In vertebrate chromosomes, the DNA component of telomeres is ...
Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells
Telomeres, the specialized nucleoproteic complexes localized at the physical ends of linear eukaryotic chromosomes, play a fundamental role in maintaining chromosomal stability and integrity, being one of the leading ...
Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
(Molecular Diversity Preservation International, 2021-06)
Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic ...
The prevalence of chromosomal aberrations in argentine air crew members
(Heldref Publications, 2009)
Chromosomal effects of infections in malnourished and eutrophic children of Gran La Plata
(Sociedad Argentina de Genética, 2008-12)
The aim of this study was to assess the induction of structural chromosomal aberrations in peripheral blood lymphocytes of malnourished and eutrophic children with bacterial infections. Thirty-six infants concurrent to the ...
DNA and chromosome damage induced by bleomycin in mammalian cells: An update
(Elsevier Science, 2018-01)
Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including ...
Interstitial telomeric sequences in vertebrate chromosomes: Origin, function, instability and evolution
(Elsevier Science, 2017-07)
By definition, telomeric sequences are located at the very ends or terminal regions of chromosomes. However, several vertebrate species show blocks of (TTAGGG)n repeats present in non-terminal regions of chromosomes, the ...
Genotoxicity evaluation of the insecticide endosulfan in the wetland macrophyte Bidens laevis L.
The frequency of micronuclei (MN) and chromosome aberrations in anaphase telophase (CAAT) was determined in root tips of the wetland macrophyte Bidens laevis exposed to environmentally relevant concentrations of endosulfan ...
Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells
(Elsevier Science, 2012-08-30)
We analyzed the induction of chromosomal aberrations in Chinese hamster ovary (CHO) cells exposed to the radiomimetic compound streptonigrin (SN), in order to determine whether interstitial telomeric sequences (ITSs) are ...
A new molecular screening tool for the detection of chromosomal abnormalities in donkeys
(Wiley Blackwell Publishing, Inc, 2019-03)
Chromosomal abnormalities are a major cause of infertility and reproductive problems in equids. Nowadays, their detection is rising due to the use of new diagnostic tools based on molecular markers instead of karyotyping. ...