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Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols
(Royal Society of Chemistry, 2013-02)
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium ...
From the molecule to the mole: improving heterogeneous copper catalyzed click chemistry using single molecule spectroscopy
(Royal Society of Chemistry, 2017-01)
Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization ...
Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs.
(Elsevier Science Inc, 2014-01)
A series of 1,2,3-triazolylsterols was prepared from pregnenolone through reductive amination and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). The newly generated stereocenter of the key propargylamino ...
Copper nanoparticles in click chemistry: an alternative catalytic system for the cycloaddition of terminal alkynes and azides
(Pergamon-Elsevier Science Ltd, 2009-03)
Readily prepared copper nanoparticles have been found to effectively catalyse the 1,3-dipolar cycloaddition of a variety of azides and alkynes furnishing the corresponding 1,2,3-triazoles in excellent yields. Both the ...
Heterogeneous photocatalytic click chemistry
(American Chemical Society, 2016-10)
Copper-doped semiconductors are designed to photoassist the alkyne-azide cycloaddition catalysis by Cu(I). Upon irradiation, injection of electrons from the semiconductor into copper oxide nanostructures produces the ...
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
(Arkat USA, 2011-02)
A series of 4-[(triazolyl)methoxy]phenyl analogs of the phenoxyphenyl-substituted thiirane SB-3CT 1 was evaluated for its ability to inhibit gelatinases, members of the matrix metalloproteinase family of enzymes. The ...
Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry
(Molecular Diversity Preservation International, 2018-06)
Naturally occurring terpenes were combined by click reactions to generate sixteen hybrid molecules. The diterpene imbricatolic acid (IA) containing an azide group was used as starting compound for the synthesis of all the ...
Química bioortogonal: cuando los organismos vivos se convierten en matraces de reacción
(Pontificia Universidad Católica del Perú, 2023)
Multicomponent click synthesis of potentially biologically active triazoles catalysed by copper nanoparticles on activated carbon in water
(Pergamon-Elsevier Science Ltd, 2012-01)
A variety of potentially biologically active 1,2,3-triazoles, derived from (-)-menthol, lactic acid, D-glucose, oestrone, cholesterol, and phenacetin, have been synthesised through the multicomponent alkyne-azide 1,3-dipolar ...
Copper Nanoparticles in Click Chemistry
(American Chemical Society, 2015-09)
The challenges of the 21st century demand scientific and technological achievements that must be developed under sustainable and environmentally benign practices. In this vein, click chemistry and green chemistry walk hand ...