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Suppressing aneuploidy-associated phenotypes improves the fitness of Trisomy 21 Cells
(Elsevier B.V., 2019-11)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular ...
Aneuploidy and tumorigenesis in Drosophila
(Academic Press Ltd - Elsevier Science Ltd, 2014-04)
Aneuploidy, described as an abnormal number of whole chromosomes or parts of them, has been observed in the majority of sporadic carcinomas, the most common type of cancer occurring in humans and derived from putative ...
Centrosome Abnormalities and Polyploidy in Murine Mammary Carcinomas with Different Degrees of Hormone Responsiveness
(Taylor & Francis, 2020-05)
Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. This study aimed to evaluate the relationship between polyploidy, centrosome ...
Epigenetic consequences of interploidal hybridisation in synthetic and natural interspecific potato hybrids
(Wiley Blackwell Publishing, Inc, 2019-06)
Interploidal hybridisation can generate changes in plant chromosome numbers, which might exert effects additional to the expected due to genome merger per se (i.e., genetic, epigenetic and phenotypic novelties).Wild potatoes ...
Estudio de las aneuploidías del cromosoma 17 y la deleción del gen TP53 en neoplasias hematológicas, por la técnica del FISH-bicolorStudy of Chromosome 17 Aneuploidy and of TP53 Gene Deletion In patients with Hematological Neoplasias by Dual-color Fluorescence in Situ Hybridization (FISH)
(Universidad de Antioquia, Facultad de MedicinaMedellín, Colombia, 2021)
Preimplantational genetic diagnosis: single aneuploidies analysisDiagnóstico genético preimplantacional: análisis de aneuploidías únicas
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana, 2013)
Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
(Nature Publishing Group, 2015-02)
When exposed to DNA-damaging agents, components of the DNA damage response (DDR) pathway trigger apoptosis, cell cycle arrest and DNA repair. Although failures in this pathway are associated with cancer development, the ...
Importancia clínica de la evaluación ecográfica de la translucencia nucal fetal
(Sociedad de Obstetricia y Ginecología de Venezuela, 2022)
Comparative cytogenetics of Physalis peruviana from three cultivated populations from Cajamarca, PeruCitogenética comparativa de Physalis peruviana en tres poblaciones cultivadas de Cajamarca, Perú
(Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, 2021)