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Toward Improving Early Diagnosis of Congenital Chagas Disease in an Endemic Setting
(Oxford University Press, 2017)
Background: Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy ...
CD4+Foxp3+T regulatory cells promote transplantation tolerance by modulating effector CD4+ T cells in a neuropilin-1-dependent manner
(Frontiers Media S.A., 2019)
Copyright © 2019 Campos-Mora, Contreras-Kallens, Gálvez-Jirón, Rojas, Rojas, Refisch, Cerda and Pino-Lagos.Several mechanisms of immune suppression have been attributed to Foxp3+ T regulatory cells (Treg) including modulation ...
IL-12 and neutralization of endogenous IL-10 revert the in vitro antigen-specific cellular immunosuppression of paracoccidioidomycosis patients
(2002-07-25)
Treatment of patients with paracoccidioidomycosis is still a challenge. Patients present defective lymphoproliferation and IFN-γ responses to the main Paracoccidioides brasiliensis antigen (gp43), which correlates with ...
IL-12 and neutralization of endogenous IL-10 revert the in vitro antigen-specific cellular immunosuppression of paracoccidioidomycosis patients
(2002-07-25)
Treatment of patients with paracoccidioidomycosis is still a challenge. Patients present defective lymphoproliferation and IFN-γ responses to the main Paracoccidioides brasiliensis antigen (gp43), which correlates with ...
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
(Macmillan Publisher Limited, 2009-05)
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding ...
Restoring Conjunctival Tolerance by Topical Nuclear Factor–κB Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice
(Association for Research in Vision and Ophthalmology, 2014-09)
Purpose.: To evaluate the role of nuclear factor–κB (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis. Methods.: Balb/c mice ...
B cells inhibit the antitumor immunity against an established murine fibrosarcoma
(Spandidos Publications, 2017-03)
Despite the classic role of B cells in favoring the immune response, an inhibitory action of B lymphocytes in tumor immunity has emerged in certain studies. In methylcolanthrene-induced murine fibrosarcoma (MCC), the loss ...
Balance between early life tolerance and sensitization in allergy: dependence on the timing and intensity of prenatal and postnatal allergen exposure of the mother
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
P>Allergens can be maternally transferred to the fetus or neonate, though it is uncertain how this initial allergen exposure may impact the development of allergy responses. To evaluate the roles of timing and level of ...