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Cytotoxic and apoptotic effects of leptocarpin, a plant-derived sesquiterpene lactone, on human cancer cell lines
(Elsevier Ireland Ltd, 2015)
Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling
(Springer, 2019)
Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector ...
Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces
(Wiley-liss, Div John Wiley & Sons Inc, 2012)
Plasmodium falciparum Field Isolates from South America Use an Atypical Red Blood Cell Invasion Pathway Associated with Invasion Ligand Polymorphisms
(Public Library of Science, 2012)
Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC) invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL) and the ...
Protective effect of nickel chloride on superoxide damage: enhancement of CuZn superoxide dismutase affinity to the oxygen free radical.
(1993-01-01)
The effect of nickel from soluble NiCl2 on Cu-Zn superoxide dismutase (SOD) activity, as well as on rate of nitro blue tetrazolium reduction, was studied in vitro since lipid peroxidation has been implicated in cell damage ...
Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru
(BioMed Central, 2012)
Background: Erythrocyte invasion by Plasmodium falciparum is a complex process that involves two families; Erythrocyte Binding-Like (EBL) and the Reticulocyte Binding-Like (PfRh) proteins. Antibodies that inhibit merozoite ...
Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships
(Wiley-Blackwell, 2017-09-01)
Falcipain-2 ( FP-2) is a major hemoglobinase of Plasmodium falciparum, considered an important drug target for the development of antimalarials. A previous study reported a novel series of 20 reversible peptide-based ...
The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials
(2007-03-01)
EPSP synthase (EPSPS) is an essential enzyme in the shikimate pathway, transferring the enolpyruvyl group of phosphoenolpyruvate to shikimate-3-phosphate to form 5-enolpyruvyl-3-shikimate phosphate and inorganic phosphate. ...