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Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF
(2011)
Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
In Silico Study of Full-Length Amyloid 1-42 Tri- and Penta-Oligomers in Solution
(American Chemical Society, 2009-11)
Amyloid oligomers are considered to play causal roles in the pathogenesis of amyloid-related degenerative diseases including Alzheimer's disease. Using MD simulation techniques, we explored the contributions of the different ...
Efeito neuroprotetor do exercício físico em um modelo de doença de alzheimer induzido pelo peptídeo β-amilóide (1-40) em camundongosNeuroprotective effect of physical exercise in a mouse model of alzheimer disease induced by β-amyloid (1-40) peptide
(Universidade Federal do PampaCampus Uruguaiana, 2016)
Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments
(2022-08)
One of the hallmarks of Alzheimer's disease is the accumulation of toxic amyloid-β (Aβ) peptides in extracellular plaques. The direct precursor of Aβ is the carboxyl-terminal fragment β (or C99) of the amyloid precursor ...
Aumento dos níveis de csf de tau total em pacientes com patologia subcutânea cerebrovascular e comprometimento cognitivo
(2017-10-01)
Cognitive impairment includes mild cognitive decline and dementia, such as Alzheimer’s disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample ...
Is it All Said for NSAIDs in Alzheimer's Disease? Role of Mitochondrial Calcium Uptake
(Bentham Science Publishers, 2018-04)
Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer´s disease (AD). Unfortunately, recent trials have failed in providing compelling evidence of neuroprotection. ...
Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease
(Elsevier Inc., 2017)
© 2017 Elsevier Inc. The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene ...
STAT3 neuronal como mediador de la toxicidad de los astrocitos estimulados con oligómeros del péptido β-amiloide
(2018)
El estrés oxidativo y la desregulación de la señalización de calcio son señales importantes en una variedad de enfermedades neurodegenerativas, incluyendo la enfermedad de Alzheimer (EA). El factor de transcripción STAT3 ...
Amyloid-β oligomers induce differential gene expression in adult human brain slices
(2012)
Cognitive decline in Alzheimer disease (AD) is increasingly attributed to the neuronal impact of soluble oligomers of the amyloid-β peptide (AβOs). Current knowledge on the molecular and cellular mechanisms underlying the ...
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease.
(2021-07-22)
Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this ...