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Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients
(Wiley, 2017)
STUDY OBJECTIVE To investigate the influence of single nucleotide polymorphisms (SNPs) in genes encoding metabolizing enzymes (CYP2C8, CYP2J2, and UGT2B7) and transporters (ABCC2 and ABCG2) on dose and dose-adjusted trough ...
Expressão dos genes CYP1A1, CYP1B1, CYP2A6 e CYP2E1 em fumantes com câncer bucal.
(Universidade Estadual Paulista (Unesp), 2018-02-05)
Os carcinógenos do tabaco estão relacionados a diversos tipos de câncer incluindo o carcinoma de células escamosas (CCE) bucal. Aliado ao álcool, o tabaco contribui para o desfecho desfavorável destes casos. A susceptibilidade ...
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population
(2011-01-19)
Abstract
Background
Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims ...
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population
(2011-01-19)
Abstract
Background
Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims ...
Frecuencias alélicas y genotípicas de los polimorfismos *2, *3 y *4 del gen CYP2C19 en poblaciones de origen Huichol, Cora y Tepehuana de Nayarit y Durango
(2011-06-14)
CYP450 genes are highly polymorphic, which determines the synthesis of enzymes with low, increased or null activity. CYP2C enzymes are well known for their ability to metabolize more than 20% of available drugs. CYP2C ...
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population
(BIOMED CENTRAL LTD, 2011)
Background: Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment. The aims of this study were to evaluate the frequencies of CYP2C19 ...
Identificación de los Polimorfismos de Nucleótido Único (SNP’S), del Citocromo P450, CYP2C9*2 Y CYP2C19*2 Y *3, en Pacientes Epilépticos
(Universidad Católica de Santa María, 2018)
Molecular confirmation of the linkage between the rhizopus oryzae CYP51A gene coding region and its intrinsic voriconazole and fluconazole resistance
(American Society for Microbiology, 2018-08)
Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant to Candida- and Aspergillus-active antifungal azole ...
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents
(American Chemical Society, 2017)