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Involvement of nitric oxide synthase in the mechanism of histamine-induced inhibition of Leydig cell steroidogenesis via histamine receptor subtypes in Sprague-Dawley rats
(Society for the Study of Reproduction, 2009-01)
The present study was conducted to shed light on the so far unexplored intracellular mechanisms underlying negative modulation of Leydig cell steroidogenesis by histamine (HA). Using the MA-10 cell line and highly purified ...
Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation
(Elsevier, 2013-01)
Long chain acyl CoA synthetase 4 (Acsl4) is a key enzyme in steroidogenesis. It participates in steroid synthesis through of arachidonic acid release and Steroidogenic Acute Regulatory protein (StAR) induction. Acsl4 prefers ...
Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions
(BIOMED CENTRAL LTDLONDON, 2012)
Background: Since noradrenergic innervation was described in the ovarian follicle, the actions of the intraovarian catecholaminergic system have been the focus of a variety of studies. We aimed to determine the ...
Mutation of HSD3B2 Gene and Fate of Dehydroepiandrosterone
(Elsevier Academic Press Inc, 2018-01)
3βHSD2 enzyme is crucial for adrenal and gonad steroid biosynthesis. In enzyme deficiency states, due to recessive loss-of-function HSD3B2 mutations, steroid flux is altered and clinical manifestations result. Deficiency ...
Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura)
(John Wiley & Sons Inc, 2018-12)
In rat Leydig cells, glucocorticoids (GCs) inhibit testosterone production through the interaction with the glucocorticoid receptor (GR). However, the sensitivity of those cells to GCs is regulated by the enzyme ...
The production of nitric oxide in the coeliac ganglion modulates the effect of cholinergic neurotransmission on the rat ovary during the preovulatory period
(Academic Press Inc Elsevier Science, 2018-05)
The aim of the present work was to investigate whether the nitric oxide produced by the nitric oxide/nitric oxide synthase (NO/NOS) system present in the coeliac ganglion modulates the effects of cholinergic innervation ...
Effect of estradiol on apoptosis, proliferation and steroidogenic enzymes in the testes of the toad Rhinella arenarum (Amphibia, Anura)
(Academic Press Inc Elsevier Science, 2015-09)
Estrogens inhibit androgen production and this negative action on amphibian steroidogenesis could be related to the regulation of steroidogenic enzymes. Estrogens are also involved in the regulation of amphibian spermatogenesis ...
Neonatal androgenization-induced early endocrine–metabolic and ovary misprogramming in the female rat
(Pergamon-elsevier Science Ltd, 2015-06)
Aim: Androgen excess predisposes the organism to develop metabolic–endocrine and reproductive dysfunctions, among them the development of a phenotype resembling that of human Polycystic Ovary Syndrome (PCOS).
Methods: ...
Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A
(Pergamon-Elsevier Science Ltd, 2016-02)
The study of oral exposure to the environmental estrogen bisphenol A (BPA) during the perinatal periodand its effects on ovarian functionality in adulthood has generated special interest. Thus, our objectivewas to investigate ...
Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?
(Elsevier B.V., 2019-01-01)
The selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. Although sexual disorders have been reported in male patients, few studies have demonstrated the fluoxetine effect on the ...