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Síntese de 1-aril-4-[(dimetilamino)metileno] pirrolidino-2,3,5-trionas utilizando irradiação de micro-ondas
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2011-02-24)
The synthesis of a series of 1-aryl-4-[(dimethylamino)methylene] pyrrolidine-
2,3,5-trione from the cyclocondensation reaction between b-enaminodiketone
[Cl3C(O)C(=CHNMe2)C(O)CO2Et] and aniline derivatives [R = Ph, 3-Me-C6H4, ...
Asymmetric construction of substituted pyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides and chiral acrylates derived from biomass
(Elsevier, 2014-03)
The first application of chiral auxiliaries synthesized from levoglucosenone (a biomass-derived anhydrosugar) in asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides is herein reported. The corresponding ...
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase i and II
(American Chemical Society, 2019-08-13)
Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increase ...