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Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells
(Elsevier Science, 2020-01)
Targeting the apoptosis machinery is a promising therapeutic approach in myeloid malignancies. BCL2L1 is a well-known glucocorticoid-responsive gene and a key apoptosis regulator that, when over-expressed, can contribute ...
Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy
(Elsevier, 2008-06)
We have analyzed the predictive/prognostic value of Bcl-2 protein in breast cancer patients treated with neoadjuvant chemotherapy. One hundred and ten patients were submitted to two different chemotherapeutic regimens: a) ...
Estudos da homeostase de cálcio celular,o cálcio e os seus estoques intracelulares(retículo endoplasma tico e mitocôndria) como sensores da vida e da morte celular
(Universidade Federal de São Paulo (UNIFESP), 2005)
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
(Nature Publishing Group, 2014-02)
Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor ...
Analysis of Ki-67 and Bcl-2 protein expression in normal colorectal mucosa of women with breast cancer
(ELSEVIER SCI LTD, 2009)
The aim of this study was to evaluate Ki-67 and Bcl-2 protein expression in the normal colorectal mucosa adjacent to adenomatous polyps in women with breast cancer. A cross-sectional, controlled study was conducted in 35 ...
Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus
(ELSEVIER SCI IRELAND LTD, 2002-10-04)
It has previously been shown that adrenalectomy (ADX) produces apoptosis in the granule cell of the dentate gyrus (DG), and that this effect is prevented by corticosterone replacement. Thus, we have investigated how this ...