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Mecanismo de regulación transcripcional de genes que codifican para receptores/canales nociceptivos del dolor P2x3 y TRPV1: Rol de Runx1.
(Universidad de Concepción.Facultad de Ciencias BiológicasDepartamento de Biología Celular y Molecular., 2011)
En mamíferos, la percepción del dolor es iniciada por la transducción de un estímulo nocivo a través de canales iónicos y receptores especializados en un grupo de células sensoriales primarias que tienen sus cuerpos celulares ...
Contrasting patterns of RUNX2 repeat variations are associated with palate shape in phyllostomid bats and New World primates
(Nature Publishing Group, 2018-12)
Establishing the genetic basis that underlies craniofacial variability in natural populations is one of the main topics of evolutionary and developmental studies. One of the genes associated with mammal craniofacial ...
Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2
(Wiley-Liss Inc., 2018)
Osteoblast differentiation is controlled by transcription factor RUNX2 which temporally activates or represses several bone-related genes, including those encoding extracellular matrix proteins or factors that control ...
Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors
(2008)
Runt-related transcription factor 2 (Runx2) controls lineage commitment, proliferation, and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. transforming growth factor-β/BMP-SMAD, ...
Rol del factor de transcripción RUNX2 en la expresión del RNA largo no codificante TALAM1 en cáncer de pulmón de células no pequeñas
El cáncer de pulmón es el tipo de cáncer que mayor mortandad tiene, llevándose la vida de millones de personas anualmente pese a las herramientas de diagnóstico y terapia disponibles actualmente. Con el objetivo de entender ...
Cissus quadrangularis Linn exerts dose-dependent biphasic effects: osteogenic and anti-proliferative, through modulating ROS, cell cycle and Runx2 gene expression in primary rat osteoblasts
(Wiley-Blackwell, 2015-08-01)
Objectives: This report highlights phytoconstituents present in Cissus quadrangularis (CQ) extract and examines biphasic (proliferative and anti-proliferative) effects of its extract on bone cell proliferation, differentiation, ...