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Role of leptin in female reproduction
(De Gruyter, 2015-01)
Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any ...
Possible crosstalk between leptin and prolactin during pregnancy
(Elsevier ScienceOxford, 2014-02-14)
Rodents exhibit leptin resistance and high levels of prolactin/placental lactogens during pregnancy. A crosstalk between prolactin and leptin signaling has been proposed as a possible mechanism to explain the changes in ...
Mesenteric adipose tissue alterations resulting from experimental, reactivated colitis
(Wiley-blackwellMaldenEUA, 2007)
TNF-alpha TRANSIENTLY INDUCES ENDOPLASMIC RETICULUM STRESS AND AN INCOMPLETE UNFOLDED PROTEIN RESPONSE IN THE HYPOTHALAMUS
(Pergamon-elsevier Science LtdOxfordInglaterra, 2010)
Obese neuronal PPARγ KO mice are leptin sensitive but show impaired glucose tolerance and fertility
(Endocrine Society, 2017-01-01)
PPARγ is expressed in the hypothalamus in areas involved in energy homeostasis and glucose metabolism. In this study, we created a deletion of PPARγ (BKO) in mature neurons in female mice to investigate its involvement in ...
Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level
(American Physiological Society, 2010-12-05)
The hypothalamic-pituitary-thyroid (HPT) axis is a major contributor in maintaining energy expenditure and body weight, and the adipocyte hormone leptin regulates this axis by increasing TRH levels in the fed state. Leptin ...
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
(Nature Publishing Group, 2001-05)
The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is associated with elevated leptin, which suggests that obese ...