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The use of antioxidants as potential co-adjuvants to treat chronic chagas disease
(MDPI, 2021)
Chagas disease is a neglected tropical disease caused by the flagellated protozoa Trypanosome cruzi. This illness affects to almost 8-12 million people worldwide, however, is endemic to Latin American countries. It is ...
A via Nrf2 participa da maior modulação endotelial induzida pela prenhez sobre reatividade de aortas à fenilefrina.
(Universidade Estadual Paulista (Unesp), 2020-09-08)
Alterações em diferentes vias de sinalização levam a disfunção vascular e endotelial e consequentemente a hipertensão. A hipertensão está relacionada diretamente com o aumento da produção de espécies reativas de oxigênio ...
Contribuição do sistema colinérgico e da sinalização do NRF2/HO-1 para a ação anti-amnésica do 7-flúor-1,3- difenilisoquinolina-1-amina em camundongos
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2019-07-26)
Dementia is a heterogenic condition characterized by different symptoms and theories about its pathogenesis, which results in difficult to understand and in the treatment of this disease. The 7-fluoro-1,3-diphenylisoquin ...
Estudio del efecto de mutaciones puntuales del péptido IDR-1002 sobre la translocación al núcleo de la proteína Nrf2, utilizando métodos experimentales y computacionales
(Universidad Michoacana de San Nicolás de Hidalgo, 2021-05)
The transcription factor Nrf2 is essential to decrease the concentration of reactive oxygen species (ROS) produced in the inflammatory response caused by tissue damage, due to oxidative stress. The disrupt of interaction ...
Análisis de la actividad del factor de transcripción Nrf2 en células HEK293 estimuladas con péptidos IDR
(Universidad Michoacana de San Nicolás de Hidalgo, 2018-08)
Oxidative stress refers to a condition in which the concentration of reactive oxygen species (ROS) surpasses the capacity of antioxidant cellular defenses. This causes alterations in the structure and function of biomolecules ...
Papel del factor de transcripción Nrf2 en el preacondicionamiento hepático inducido por hierro y hormona tiroídea, frente a isquemiareperfusión en ratas
(Universidad de Chile, 2014)
El metabolismo celular aeróbico está asociado a la generación de especies pro oxidantes que pueden dañar biomoléculas contribuyendo a la generación de enfermedades y
al envejecimiento celular. El estrés oxidativo (EOx) ...
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
(2012)
Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...
Nitric oxide sets off an antioxidant response in adrenal cells: Involvement of sGC and Nrf2 in HO-1 induction
(Elsevier Inc, 2013-12)
Induction of microsomal heme oxygenase 1 (HO-1) activity is considered a cytoprotective mechanism in different cell types. In adrenal cells, HO-1 induction by ACTH exerts a modulatory effect on steroid production as well. ...