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Mostrando ítems 31-40 de 78
Caracterização molecular de proteínas que compõem o complexo spliceosomal em tripanosomatídeos
(Universidade Estadual Paulista (Unesp), 2008-11-14)
Em tripanosomatideos, o processo de trans-splicing é responsável pelo processamento dos pré-mRNAs policistrônicos, resultando na individualização de cada gene, de modo que cada mRNA contenha a seqüência spliced leader (SL) ...
The Arabidopsis lncRNA ASCO modulates the transcriptome through interaction with splicing factors
(Nature Publishing Group, 2020-04)
Alternative splicing (AS) is a major source of transcriptome diversity. Long noncoding RNAs (lncRNAs) have emerged as regulators of AS through different molecular mechanisms. In Arabidopsis thaliana, the AS regulators NSRs ...
How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?
(Elsevier Science London, 2016-10)
The splice sites (SSs) delimiting an intron are brought together in the earliest step of spliceosome assembly yet it remains obscure how SS pairing occurs, especially when introns are thousands of nucleotides long. Splicing ...
Role for LSM genes in the regulation of circadian rhythms
(National Academy Of Sciences, 2014-10)
Growing evidence suggests that core spliceosomal components differentially affect RNA processing of specific genes; however, whether changes in the levels or activities of these factors control specific signaling pathways ...
Mapping of the protein-binding interface between splicing factors SF3b155 and p14 of Trypanosoma cruzi
(Academic Press Inc Elsevier Science, 2007-12)
SF3b155 and p14 are essential components of spliceosome core that recognize the branch point adenosine, a critical step in splicing in eukaryotes. Trypanosomes are unusual since every transcribed gene is processed by ...
Chromosome Mapping of U2 snDNA in Species of Leptodactylus (Anura, Leptodactylidae)
(2021-01-01)
Small nuclear RNA (snRNA) is a class of molecules involved in the processing of pre-mRNA and in regulatory cell processes. snRNAs are always associated with a set of specific proteins. The complexes are referred to as small ...
Environmental stresses inhibit splicing in the aquatic fungus Blastocladiella emersonii
(BIOMED CENTRAL LTD, 2009)
Background: Exposure of cells to environmental stress conditions can lead to the interruption of several intracellular processes, in particular those performed by macromolecular complexes such as the spliceosome. Results: ...
RNA metabolism and ubiquitin/ubiquitin-like modifications collide
(Oxford University Press, 2012-11)
Alternative splicing and post-translational modifications are key events for the generation of proteome diversity in eukaryotes. The study of the molecular mechanisms governing these processes, and every other step of gene ...
U1 snDNA clusters in grasshoppers: chromosomal dynamics and genomic organization
(Nature Publishing Group, 2015-02-01)
The spliceosome, constituted by a protein set associated with small nuclear RNA (snRNA), is responsible for mRNA maturation through intron removal. Among snRNA genes, U1 is generally a conserved repetitive sequence. To ...
PRP8 intein in dermatophytes: Evolution and species identification
(Oxford Univ Press, 2018-08-01)
Dermatophytes are keratinophilic fungi belonging to the family Arthrodermataceae. Despite having a monophyletic origin, its systematics has always been complex and controversial. Sequencing of nuclear ribosomal ITS and ...