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Mostrando ítems 31-40 de 1021
Novel insights into the pathogenesis of diabetic cardiomyopathy and pharmacological strategies
(Frontiers Media, 2021)
Diabetic cardiomyopathy (DCM) is a severe complication of diabetes developed mainly in
poorly controlled patients. In DCM, several clinical manifestations as well as cellular and
molecular mechanisms contribute to its ...
Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways
(Nature Publishing Group, 2015-12)
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma. Consistent with the high morbidity levels ...
Human α-galactosidase a mutants: Priceless tools to develop novel therapies for fabry disease
(MDPI AG, 2021-06)
Fabry disease (FD) is a lysosomal storage disease caused by mutations in the gene for the α-galactosidase A (GLA) enzyme. The absence of the enzyme or its activity results in the accumulation of glycosphingolipids, mainly ...
N-3 Polyunsaturated Fatty Acids and Their Lipid Mediators as A Potential Immune-Nutritional Intervention: A Molecular and Clinical View in Hepatic Disease and Other Non-Communicable Illnesses
(MDPI, 2021)
In recent years, the beneficial effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) intake on human health has been widely accepted in the field of immunonutrition. Today, we find a diversity of supplements based on n-3 ...
Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance
(Elsevier, 2012)
Pyrazinamide is one of the most important drugs in the treatment of latent Mycobacterium tuberculosis infection. The emergence of strains resistant to pyrazinamide represents an important public health problem, as both ...
Clinical, genomic, and pharmacological study of MYCN-amplified RB1 wild-type metastatic retinoblastoma
(Molecular Diversity Preservation International, 2020-09)
An uncommon subgroup of unilateral retinoblastomas with highly aggressive histological features, lacking aberrations in RB1 gene with high-level amplification of MYCN (MCYNampl RB1+/+) has only been described as intra-ocular ...
Guadalajara camptodactyly type III: A new probably autosomal dominant syndrome
(2014)
High-content screening led to the identification of the N-isobutylamide guineensine from Piper nigrum as novel nanomolar inhibitor (EC50 = 290 nM) of cellular uptake of the endocannabinoid anandamide (AEA). Noteworthy, ...
Pimecrolimus 1% cream for the treatment of discoid lupus erythematosus
(2012)
Polarized T helper type 2 (Th2) response is linked with fibrosis. Here, we evaluated the effect of the anti-fibrotic agent pirfenidone on Th type 1 (Th1) and Th2 responses. For in vivo testing; Wistar rats were made cirrhotic ...
Melatonin and periodontal tissues: Molecular and clinical perspectives
(Academic Press Ltd - Elsevier Science Ltd, 2017-11)
Periodontal disease is a frequent chronic inflammatory pathology that implies the destruction of the tissues supporting the teeth, which represents a high sanitary cost. It usually appears associated with other systemic ...