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Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses
(Kluwer Academic/plenum Publ, 2004)
Galectins are a large family of structurally related beta-galactoside-binding proteins that play a pivotal role in the control of cell differentiation, proliferation, activation and apoptosis of many different cell types ...
Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response
(Scion Publishing Ltd, 2007)
Protein-glycan interactions mediate a variety of biological processes including cell trafficking, activation, differentiation, and survival. Galectins, a growing family of animal lectins defined by shared consensus amino ...
'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
(Wiley Blackwell Publishing, Inc, 2013-04-14)
Successful mammalian pregnancy relies upon acceptance of a semi-allogeneic fetus by the maternal immune system. Lessons learned from studies on protective immunity to microbial infections and tumours, prevention of ...
"Time sweet time": circadian characterization of galectin-1 null mice
(BioMed Central, 2010-04-19)
Recent evidence suggests a two-way interaction between the immune and circadian systems. Circadian control of immune factors, as well as the effect of immunological variables on circadian rhythms, might be key elements in ...
Impact of Galectins in Resistance to Anticancer Therapies
(American Association for Cancer Research, 2020-07)
Galectins are an endogenous family of β-galactoside-binding proteins that play complex and multifaceted roles at various stages of cancer progression, including modulation of tumor cell proliferation, signaling, adhesion, ...
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
(Nature Publishing Group, 2011-11)
Galectins control critical pathophysiological processes, including the progression and resolution of central nervous system (CNS) inflammation. In spite of considerable progress in dissecting their role within lymphoid ...
Differential expression of galectin-3, beta-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Background: Galectin-3 has been implicated in tumor progression of some malignancies as thyroid, prostate, and salivary gland tumors. Recently, it has been suggested that this protein may be an important mediator of the ...
Galectin-3 Overexpression in Invasive Laryngeal Carcinoma, Assessed by Computer-assisted Analysis
(Histochemical Soc Inc, 2009-07-01)
The larynx is the most common site of malignancy in the upper aerodigestive tract. In Brazil, malignant laryngeal lesions represent 2% of all cancers, with similar to 3000 annual deaths. The association between human ...
Galectin-3 Overexpression in Invasive Laryngeal Carcinoma, Assessed by Computer-assisted Analysis
(Histochemical Soc Inc, 2009-07-01)
The larynx is the most common site of malignancy in the upper aerodigestive tract. In Brazil, malignant laryngeal lesions represent 2% of all cancers, with similar to 3000 annual deaths. The association between human ...
Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
(Frontiers Media S.A., 2018-03)
Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. ...