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Distinctive Immunomodulatory and Inflammatory Properties of the Escherichia coli Type II Heat-Labile Enterotoxin LT-IIa and Its B Pentamer following Intradermal Administration
(AMER SOC MICROBIOLOGY, 2011)
The type I and type II heat-labile enterotoxins (LT-I and LT-II) are strong mucosal adjuvants when they are coadministered with soluble antigens. Nonetheless, data on the parenteral adjuvant activities of LT-II are still ...
Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells
(2019-01-07)
Functionalized MCM-41 is a class of new nanoporous biomaterials extensively studied as drug carriers of a diversity of therapeutic agents due to its suitable properties. In the present study, two oxindolimine complexes ...
Drug delivery systems for local anesthetics
(2010-06-25)
Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local ...
Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae
(Wiley Blackwell Publishing, Inc, 2008-08)
Lactococcus lactis NZ9000 is a non-pathogenic non-invasive bacterium extensively used for the delivery of antigens and cytokines at the mucosal level. However, there are no reports concerning the per se immunomodulatory ...
Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment
(Elsevier Science, 2018-10)
The use of hybrid materials, where a matrix sustains nanoparticles controlling the release of the chemotherapeutic drug, could be beneficial for the treatment of primary tumors prior or after surgery. This localized ...
A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses
(Elsevier Science, 2015-12)
We report here that a bacterial protease inhibitor from Brucella spp. called U-Omp19 behaves as an ideal constituent for a vaccine formulation against infectious diseases. When co-administered orally with an antigen (Ag), ...
Alginate-chitosan systems: In vitro controlled release of triamcinolone and in vivo gastrointestinal transit
(Elsevier B.V., 2010-06-11)
The aim of this study was to develop multiparticulate therapeutic systems of alginate (AL) and chitosan (CS) containing triamcinolone (TC) to colonic drug delivery. Multiparticulate systems of AL-CS, prepared by a complex ...
Alginate-chitosan systems: In vitro controlled release of triamcinolone and in vivo gastrointestinal transit
(Elsevier B.V., 2010-06-11)
The aim of this study was to develop multiparticulate therapeutic systems of alginate (AL) and chitosan (CS) containing triamcinolone (TC) to colonic drug delivery. Multiparticulate systems of AL-CS, prepared by a complex ...
The Chlamydia M278 Major outer membrane peptide encapsulated in the poly(lactic acid)-poly(ethylene glycol) nanoparticulate self-adjuvanting delivery system protects mice against a Chlamydia muridarumgenital tract challenge by stimulating robust systemic and local mucosal immune responses
(Frontiers Media S.A., 2018-10)
Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric PLA-PEG (poly(lactic acid)-poly(ethylene glycol))-encapsulated M278 peptide (derived from the major outer membrane protein (MOMP) of ...