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Fluoride absorption from disodium and calcium monofluorophosphates from the gastrointestinal tract of rats
(1993)
The contribution of the stomach and the small intestine to the in vivo absorption of fluoride from disodium and calcium monofluorophosphates was studied in comparison with that observed when sodium fluoride is given to ...
The 1,2,3-benzothiadiazoles. A new type of compound acting on coupling site i, in rat liver mitochondria
(Informa Healthcare, 1980)
1. In rat liver mitochondria, 6-chloro-1,2,3-benzothiadiazole inhibited ADP phosphorylation and Ca2+-transport when the energy required for these processes came from the oxidation of NAD-linked substrates. The inhibition ...
Effect of phenobarbital and 3-methylcholanthrene on the early oxidative stress component induced by lindane in rat liver
(Informa Healthcare, 1991)
1. Lindane administered to untreated rats or rats pretreated with phenobarbital (PB) or 3-methylcholanthrene (MC) increased liver lipid peroxidation, of the same magnitude in all groups. 2. PB pretreatment produced a 50% ...
2,2'azo-bis-amidinopropane as a radical source for lipid peroxidation and enzyme inactivation studies
(Informa Healthcare, 1991)
1. 2,2'Azo-bis-amidinopropane (ABAP) thermal decomposition produces free radicals that initiate the lipid peroxidation of erythrocyte ghost membranes. 2. Addition of 6-n-propyl-2-thiouracil decreases the rate of the process, ...
Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects?
The COVID-19 outbreak emerged in December 2019 and has rapidly become a global pandemic. A great deal of
effort has been made to find effective drugs against this disease. Chloroquine (CQ) and hydroxychloroquine
(HCQ) ...
Induction of rat hepatic p4501a1 by organic extracts from airborne particulate matter in Santiago, Chile
(Informa Healthcare, 1995)
1. Organic extracts from particulate matter collected in downtown Santiago, Chile, in 1990 were administered to female Wistar rats. 2. Extracts shifted the maximal absorption wavelength P450 spectra of the reduced-CO complex ...
Dose-dependent effects of acute lindane treatment on Kupffer cell function assessed in the isolated perfused rat liver
(1997)
1. Twenty-four hours after lindane exposure (5-60 mg/kg) a dose-dependent increase in the serum and hepatic levels of the insecticide was observed. Both the basal rate of O2 consumption and the sinusoidal efflux of lactate ...
Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status
(Informa Healthcare, 1988)
1. Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22% and GSSG was increased (20% while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. ...
Lindane-induced oxidative stress. I. Time course of changes in hepatic microsomal parameters, antioxidant enzymes, lipid peroxidative indices and morphological characteristics
(Informa Healthcare, 1988)
1. Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O- 2) generation 24 h after treatment, while formation of thiobarbituric acid reactants and NADPH/ADP-supported ...
Flumecinol, a novel inducer of testosterone 16a-hydroxylation in Male rats
(Informa Healthcare, 1990)
1. Flumecinol, a new inducer of the cytochrome P-450 monooxygenases, was studied in rats as a possible effector of liver microsomal testosterone oxidases. The drug enhanced the total content of liver cytochrome P-450 in ...