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New small-size peptides modulators of the exosite of BACE1 obtained from a structure-based design
(Taylor & Francis, 2016-03)
We report here two new small-size peptides acting as modulators of the β-site APP cleaving enzyme 1 (BACE1) exosite. Ac-YPYFDPL-NH2 and Ac-YPYDIPL-NH2 displayed a moderate but significant inhibitory effect on BACE1. These ...
Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2-and gamma-secretase inhibitors
(Ferrata Storti FoundationPaviaItália, 2010)
Alpha-secretase-derived fragment of cellular prion, n1, protects against monomeric and oligomeric amyloid beta (a beta)-associated cell deathJOURNAL OF BIOLOGICAL CHEMISTRYJ BIOL CHEM
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012)
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processingMOLECULAR BIOLOGY OF THE CELLMOL BIOL CELL
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)
Effects of an inhibitor of the gamma-secretase complex on proliferation and apoptotic parameters in a FOXL2-mutated granulosa tumor cell line (KGN).
(Soc Study Reproduction, 2013-07-11)
Ovarian granulosa cell tumors (GCTs) represent 3%-5% of all ovarian malignancies. Treatments have limited proven efficacy and biologically targeted treatment is lacking. The aim of this study was to investigate the role ...
QSAR Classification Models for Predicting the Activity of Inhibitors of Beta-Secretase (BACE1) Associated with Alzheimer’s Disease
(Nature Publishing Group, 2019-06-24)
Alzheimer’s disease is one of the most common neurodegenerative disorders in elder population. The β-site amyloid cleavage enzyme 1 (BACE1) is the major constituent of amyloid plaques and plays a central role in this brain ...
Effect of BACE1-inhibited astrocytes on endothelial cells in a glutamate toxic environment
(Grupo de Neurociencias de AntioquiaMedellín, Colombia, 2020)
Expresión de BACE-1 y su asociación con astrogliosis y taupatía en demencias
(Grupo de Neurociencias de AntioquiaEl Carmen de Viboral, Colombia, 2020)