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NLRP3 INFLAMMASOME CONTRIBUTION TO HOST PROTECTION DURING INFECTION BY SPOROTHRIX SCHENCKII
(Elsevier B.V., 2016-11-01)
Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection
(Public Library of Science, 2015)
Pharmacological blockade of NLRP3 inflammasome/IL1β-positive loop mitigates endothelial cell senescence and dysfunction
(International Society on Aging and Disease, 2022)
The clinical relevance of IL-1 beta in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition of the cytokine with lower cardiovascular risk. Previously, ...
Annexin A1 Regulates NLRP3 Inflammasome Activation and Modifies Lipid Release Profile in Isolated Peritoneal Macrophages
(Mdpi, 2020-04-01)
Annexin A1 (AnxA1) is a potent anti-inflammatory protein that downregulates proinflammatory cytokine release. This study evaluated the role of AnxA1 in the regulation of NLRP3 inflammasome activation and lipid release by ...
Associação de biomarcadores do inflamassoma às diferentes formas imunopatológicas da hanseníase
(Universidade Federal de Minas GeraisUFMG, 2017-02-22)
Leprosy still remains a serious public health problem in Brazil. This neglected disease has a wide range of clinical and histopathological manifestations which are related to the host inflammatory and immune responses. ...
Cathepsin L3 from fasciola hepatica induces NLRP3 inflammasome alternative activation in murine dendritic cells
(Frontiers Media S.A., 2019-03)
The production of IL-1-family cytokines such as IL-1β and IL-18 is finely regulated by inflammasome activation after the recognition of pathogens associated molecular pattern (PAMPs) and danger associated molecular patterns ...