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Hydrogen Sulfide Regulates Inward-Rectifying K+ Channels in Conjunction with Stomatal Closure
(American Society of Plant Biologist, 2015-05)
Hydrogen sulfide (H2S) is the third biological gasotransmitter, and in animals, it affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse ...
Marine Toxins Targeting Ion Channels
(Molecular Diversity Preservation International, 2006-04)
This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ...
Average channel capacity for generalized fading scenarios
(Ieee-inst Electrical Electronics Engineers IncPiscatawayEUA, 2007)
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block
(ROCKEFELLER UNIV PRESS, 2008-02)
The internal vestibule of large-conductance Ca2+ voltage-activated K+ (BK) channels contains a ring of eight negative charges not present in K+ channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel ...
Voltage-Gated K+/Na(+)Channels and Scorpion Venom Toxins in Cancer
(Frontiers Media, 2020)
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, ...
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker
(NATL ACAD SCIENCES, 2001-08-14)
Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu, This charge movement leads to channel opening. In ...
CALCIUM ACTIVATION OF K+ CHANNELS: RCK DOMAINS
(SPRINGER, 2013)
Some K+ channels can be activated by a rise in cytosolic Ca2+ and, in two cases (the K+ channels from the archeon Methanobacterium thermoautotrophicum (MthK) and the large conductance voltage- and Ca2+-activated K+ (BK) ...
The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
(Wiley, 2017)
Background-Heterozygous loss of function mutations in the KCNK3 gene cause hereditary pulmonary arterial hypertension (PAH). KCNK3 encodes an acid-sensitive potassium channel, which contributes to the resting potential of ...