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The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events
(American Society for Microbiology, 2010-03)
In this study, we demonstrate that the subcellular localization of the mineralocorticoid receptor (MR) is regulated by tetratricopeptide domain (TPR) proteins. The high-molecular-weight immunophilin (IMM) FKBP52 links the ...
Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice
(MDPI, 2020)
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid ...
Mentalization and epigenetic changes in psycotherapy of adolescents diagnosed with borderline personality disorder
(2021)
Genetic and early environmental factors are interwoven in the etiopathogenesis of
Borderline Personality Disorder (BPD). Epigenetic mechanisms, allow the molecular
machinery to adapt to environmental conditions. There ...
Role of the Hsp90-immunophilin heterocomplex in cancer disease
(Bentham Science Publishers, 2019)
The identification of new factors that may function as cancer markers and becomeeventual pharmacologic targets is a challenge that may influence the management of tumor developmentand management. Recent discoveries connecting ...
Differential regulation of the glucocorticoid receptor nucleocytoplasmic shuttling by TPR-domain proteins
(Elsevier Science, 2021-05)
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90 dimer shapes a functional ...
Neuroregenerative and neuroprotective actions of immunophilin ligands in murine models
(Fundación Revista Medicina, 2017)
Immunophilins (IMMs) are a family of intracellular proteins that bind immunosuppressive drugs. They are referred to as FK506-binding proteins (FKBPs) when they bind FK506, and cyclophilins (CyPs) when they bind cyclosporine ...
Heme Oxygenase 1 Impairs Glucocorticoid Receptor Activity in Prostate Cancer
(Molecular Diversity Preservation International, 2019-02)
Glucocorticoids are used during prostate cancer (PCa) treatment. However, they may also have the potential to drive castration resistant prostate cancer (CRPC) growth via the glucocorticoid receptor (GR). Given the association ...
Neuroprotective effect of FK506 against oxidative stress
(Sociedad Argentina de Neurociencias, 2020)