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Influência do bloqueio do receptor at1 sobre os colágenos I e III miocárdico de ratos obesos por dieta hiperlipídica saturada
(Universidade Estadual Paulista (Unesp), 2016-07-08)
A obesidade se associa a inúmeros distúrbios modulados pelo sistema renina angiotensina (SRA) e embora exista uma extensa literatura mostrando a relação entre a angiotensina II e o metabolismo do colágeno miocárdico, não ...
Higher salt preference in heart failure patients
(Academic Press Ltd Elsevier B.V. Ltd, 2012-02-01)
Heart failure (HF) is a complex syndrome that involves changes in behavioral, neural and endocrine regulatory systems. Dietary salt restriction along with pharmacotherapy is considered an essential component in the effective ...
Higher salt preference in heart failure patients
(Academic Press Ltd Elsevier B.V. Ltd, 2012-02-01)
Heart failure (HF) is a complex syndrome that involves changes in behavioral, neural and endocrine regulatory systems. Dietary salt restriction along with pharmacotherapy is considered an essential component in the effective ...
Angiotensin II requires an intact cardiac Thyrotropin-Releasing Hormone (TRH) system to Induce cardiac hypertrophy in mouse
(Academic Press Ltd - Elsevier Science Ltd, 2018-11)
Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, ...
A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes
(Elsevier B.V., 2009-11-27)
In a previous paper we demonstrated that Ang-(3-4) counteracts inhibition of the Ca(2+)-ATPase by Ang II in the basolateral membranes of kidney proximal tubules cells (BLM). We have now investigated the enzymatic routs by ...
Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats
(AMER PHYSIOLOGICAL SOC, 2004-02-01)
In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
Mitochondrial function and nitric oxide metabolism are modified by enalapril in rat kidney
(American Physiological Society, 2007-04)
The renal and cardiac benefits of renin-angiotensin system (RAS) inhibition in hypertension exceed those attributable to blood pressure reduction, and seem to involve mitochondrial function changes. To investigate whether ...
Effects of AT1 receptor antagonism on interstitial and ultrastructural remodeling of heart in response to a hypercaloric diet
(2019-01-01)
Palatable hypercaloric feeding has been associated with angiotensin-II type 1 receptor (AT1R) stimulation and cardiac remodeling. This study analyzed whether AT1R antagonism attenuates cardiac remodeling in rats subjected ...
Avaliação da Cardioproteção em Ratos que Superexpressam uma Proteína de Fusão Produtora de Angiotensina-(1-7) [TGR(A1-7)3292]
(Universidade Federal de Minas GeraisUFMG, 2006-12-20)
Angiotensin-(1-7) (Ang-(1-7) is now considered to be a biologically active member of the renin-angiotensin system. The functions of Ang-(1-7) are often opposite to those attributed to the main effector component of the ...