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Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology
(Nature Publishing Group, 2015-07)
Galectin-1 (Gal-1), a proto-type member of galectin family, is highly expressed in immune privileged sites, including the testis. However, in spite of considerable progress the relevance of endogenous and exogenous Gal-1 ...
IL17A impairs blood-testis barrier integrity and induces testicular inflammation
(Springer, 2014-09)
Experimental autoimmune orchitis is a useful model for studying testicular inflammation and germ/immune cell interactions. Th17 cells and their hallmark cytokine IL17A were reported to be involved in the development of ...
Evaluation of testicular sperm CRISP2 as a potential target for contraception
(American Society of Andrology, 2012-11-12)
Cysteine-rich secretory protein 2 (CRISP2) is a testicular sperm protein proposed to be involved in fertilization. With the aim of examining the relevance of CRISP2 for fertility and its potential use as a target for ...
Dual role of immune cells in the testis: protective or pathogenic for germ cells?
(Taylor & Francis, 2013-01)
The purpose of this review is to describe how the immune cells present in the testis interact with the germinal epithelium contributing to survival or apoptosis of germ cells (GCs). Physiologically, the immunosuppressor ...