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The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells
(Elsevier, 2013-07)
Introduction: Reactive oxygen species (ROS) are produced by a number of physiological and pathological processes which influence the function of a diverse array of cellular events. An imbalance between ROS generation and ...
Thyroid hormone administration induces rat liver Nrf2 activation: Suppression by N-acetylcysteine pretreatment
(2011)
Background: Oxidative stress associated with 3,3′,5-triiodo-l- thyronine (T3)-induced calorigenesis upregulates the hepatic expression of mediators of cytoprotective mechanisms. The aim of this study was to evaluate the ...
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
(2018)
The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include activation of Ca2+ ...
Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis
(2017-05-01)
Protandim and 6-gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the ...
Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566
(Wiley, 2017)
Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP). Among these disorders, fragile X syndrome (FXS) is the most ...
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and Chagasic patients: The role of Nrf1/2 and antioxidant response
(American Heart Association, 2012-11-29)
Mitochondrial dysfunction is a key determinant in chagasic cardiomyopathy development in mice; however, its relevance in human Chagas disease is not known. We determined if defects in mitochondrial biogenesis and dysregulation ...
Participación de las especies reactivas del oxígeno y NRF2 en la señalización intracelular inducida por BDNF en neuronas hipocampales
(Universidad de Chile, 2017)
El factor neurotrófico derivado del cerebro (BDNF) es clave para la plasticidad
sináptica hipocampal y la memoria espacial. La unión de BDNF a su receptor TrkB
activa cascadas de señalización intracelular que involucran ...