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Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1
(ROCKEFELLER UNIV PRESS, 2003-10)
Animal and plant voltage-gated ion channels share a common architecture. They are made up of four subunits and the positive charges on helical S4 segments of the protein in animal K+ channels are the main voltage-sensing ...
Role Of The Fenestrations For The Binding Of A1899 To Task-1 Potassium Channel
(2016)
A1899 is a potent and highly selective antagonist of the two-pore domain potassium (K2P) channel TASK-1. It was
previously reported that A1899 acts as an open-channel blocker and binds to residues of the P1, P2 regions, ...
Intracellular Blockers Design Targeting TASK-3 Potassium Channels
(2015)
TASK-‐3
is
a
two-‐pore
domain
potassium
(K2P)
channel
highly
expressed
in
hippocampus,
cerebellum
and
cortex.
TASK-‐3
regulates
neurotransmitter
functions
as
well
as
the
mediating
effect
of
the
neurotransmitter
activa ...
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
(ROCKEFELLER UNIV PRESS, 2006-02)
High conductance, calcium- and voltage-activated potassium (BK, MaxiK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory ...
Differential Expression of Potassium Channels in Placentas from Normal and Pathological Pregnancies: Targeting of the Kir 2.1 Channel to Lipid Rafts
(Springer, 2012-03)
Potassium channels play important physiological roles in human syncytiotrophoblasts (hSTBs) from placenta, an epithelium responsible for maternal-fetal exchange. Basal and apical plasma membranes differ in their lipid and ...
The role of potassium channels in the vasodilatory effect of caffeine in human internal mammary arteries
There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the ...
Orientation of Arabidopsis thaliana KAT1 channel in the plasma membrane
(2004)
The Arabidopsis thaliana KAT1, an inward-rectifying potassium channel, shares molecular features with the Shaker family of outward rectifier K(+) channels. The KAT1 amino-acid sequence reveals the presence of a positively ...