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Mapping the neurosteroid binding sites on glycine receptors
(Pergamon-Elsevier Science Ltd, 2019-09)
Glycine is a major inhibitory neurotransmitter in the CNS, where it modulates both sensory and motor transduction throughout its binding to glycine receptors (GlyRs), pentameric chloride channels that share structural and ...
Racemic salsolinol and its enantiomers act as agonists of the µ-opioid receptor by activating the Gi protein-adenylate cyclase pathway
(Frontiers Media S.A., 2017)
© 2017 Berríos-Cárcamo, Quintanilla, Herrera-Marschitz, Vasiliou, Zapata-Torres and Rivera-Meza. Background: Several studies have shown that the ethanol-derived metabolite salsolinol (SAL) can activate the mesolimbic system, ...
Molecular function of α7 nicotinic receptors as drug targets
(Wiley Blackwell Publishing, Inc, 2018-05-13)
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to ...
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
(American Society for Pharmacology and Experimental Therapeutics, 2006-12)
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs. The anthelmintic agents ...
In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus
(Blackwell Publishing LtdOxfordInglaterra, 2004)
Regulation of GABAA receptors by prolonged exposure to endogenous and exogenous ligands
(Pergamon-Elsevier Science Ltd, 2018-09)
GABAA receptors mediate most of the fast inhibitory transmissions in the central nervous system. These receptors are pentameric complexes that exhibit high structural and pharmacological heterogeneity, as they can be ...
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...
Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways
(Nature Publishing Group, 2015-12)
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma. Consistent with the high morbidity levels ...