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Endothelial dysfunction in DOCA-salt hypertension - Possible involvement of prostaglandin endoperoxides
(Elsevier B.V., 1999-03-01)
The effects of the arachidonic acid metabolism inhibitors on the acetylcholine responses of aortae from control (CR) and deoxycorticosterone acetate (DOCA)-salt hypertensive (HR) rats were investigated. The acetylcholine ...
Endothelial dysfunction in DOCA-salt hypertension - Possible involvement of prostaglandin endoperoxides
(Elsevier B.V., 1999-03-01)
The effects of the arachidonic acid metabolism inhibitors on the acetylcholine responses of aortae from control (CR) and deoxycorticosterone acetate (DOCA)-salt hypertensive (HR) rats were investigated. The acetylcholine ...
Diverse effects of renal denervation on ventricular hypertrophy and blood pressure in DOCA-salt hypertensive rats
(1998-04)
Cardiac hypertrophy that accompanies hypertension seems to be a phenomenon of multifactorial origin whose development does not seem to depend on an increased pressure load alone, but also on local growth factors and ...
DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosurn
(NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2008)
The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are ...
Pyk2 mediates increased adrenergic contractile responses in arteries from DOCA-salt mice - Vasoactive Peptide Symposium
(ELSEVIER SCIENCE INC, 2008)
The calcium-dependent proline-rich tyrosine kinase (Pyk2), a nonreceptor protein activated by tyrosine phosphorylation, links G protein-coupled receptors to vascular responses. We tested the hypothesis that enhanced vascular ...
Alterations in vasoconstrictor responses to the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in DOCA-salt hypertensive rats
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDLONDON, 2012)
Uridine adenosine tetraphosphate (Up(4)A) has been recently identified as a novel and potent endothelium-derived contracting factor and contains both purine and pyrimidine moieties, which activate purinergic P2X and P2Y ...
Mineralocorticoid treatment upregulates the hypothalamic vasopressinergic system of spontaneously hypertensive rats
(Karger, 2004)
Mineralocorticoid effects in the brain include the control of cardiovascular functions, induction of salt appetite, interaction with the vasoactive neuropeptides arginine vasopressin (AVP) and angiotensin II and development ...
Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes
(Lippincott Williams and Wilkins, 2014)
Adaptive immune response has been implicated in inflammation and fibrosis as a result of exposure to mineralocorticoids and a high-salt diet. We hypothesized that in mineralocorticoid-salt-induced hypertension, activation ...
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
(American Physiological Society, 2000-07)
To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 ...