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Changes in calsequestrin, TNF-alpha, TGF-beta and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles
(Wiley-Blackwell, 2015-10-01)
In Duchenne muscular dystrophy (DMD), the search for new biomarkers to follow the evolution of the disease is of fundamental importance in the light of the evolving gene and pharmacological therapies. In addition to the ...
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2010-04-01)
Background: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta and transforming ...
Absence of transforming growth factor-beta type II receptor is associated with poorer prognosis in HER2-negative breast tumours
(Oxford University Press, 2010-04-01)
Background: The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta and transforming ...
Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients
(Elsevier, 2018-01)
Introduction Tumour burden is a prognostic biomarker in metastatic melanoma. However, tumour burden is difficult to measure and there are currently no reliable surrogate biomarkers to easily and reliably determine it. The ...
Clinical value of carcinoembryonic antigen in mammary neoplasms of bitches
(2020-09-01)
This study aimed at evaluating the behaviour and understanding the diagnostic value of the carcinoembryonic antigen (CEA) in bitches with mammary carcinoma as a tool for monitoring and prognosis of canine cancer patients. ...
Evidence of epithelial-mesenchymal transition in canine prostate cancer metastasis
(Elsevier B.V., 2015-06-01)
The epithelial mesenchymal transition (EMT) is a fundamental event responsible for the invasiveness and metastasis of epithelial tumours. The EMT has been described in many human cancers, but there are few reports of this ...
The ERα membrane pool modulates the proliferation of pituitary tumours
(BioScientifica, 2019-02)
The molecular mechanisms underlying the ERα nuclear/cytoplasmic pool that modulates pituitary cell proliferation have been widely described, but it is still not clear how ERα is targeted to the plasma membrane. The aim of ...