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Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling
(Springer, 2019)
Allostery is a basic principle that enables proteins to process and transmit cellular information. Protein kinases evolved allosteric mechanisms to transduce cellular signals to downstream signalling components or effector ...
Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway
(NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 2007-05)
Prostate cancer represents a major concern in human oncology and the phytoalexin resveratrol (RES) inhibits growth and
proliferation of prostate cancer cells through the induction of apoptosis. In addition, previous data ...
The role of PI3K alpha isoform in cardioprotection
(Springer, 2017)
Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, ...
Pi3k Inhibition Synergizes With Glucocorticoids But Antagonizes With Methotrexate In T-cell Acute Lymphoblastic Leukemia
(IMPACT JOURNALS LLCALBANY, 2015)
Targeted therapy to annihilate the immune-evading phenotype in cancer evolution
(Informa Healthcare, 2018-07)
Cancer is a moving target, and targeted therapy must ultimatelydeal with the evolution of the disease. This is becauseevolution is the substrate for development of resistance totargeted therapy. A successful therapeutic ...
Increased vascular O-GlcNAcylation augments reactivity to constrictor stimuli - Vasoactive Peptide Symposium
(ELSEVIER SCIENCE INC, 2008)
O-linked N-acetylglucosaminylation (O-GlcNAcylation) plays a role in many aspects of protein function. Whereas elevated O-GlcNAc levels contribute to diabetes-related end-organ damage, O-GlcNAcylation is also physiologically ...
Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes
(Nature Publishing GroupNew YorkEUA, 2009)
A Chemical Biology Approach to Understand The Regulation Of Full-Length Phosphoinositide-Dependent Protein Kinase 1 (Pdk1)
(Biocell, 2019)
Phosphoinositide-dependent protein kinase 1 (PDK1) is a master AGC kinase that phosphorylates at least other 23 AGC kinases, being PKB/Aktthe most relevant substrate downstream of PI3-kinase, important for growth and cell ...
Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis
(American Society of Plant Biologists, 2014)
Cell polarity manifested by asymmetric distribution of cargoes, such as receptors and transporters, within the plasma membrane (PM) is crucial for essential functions in multicellular organisms. In plants, cell polarity ...