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Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats
(F Hernandez, 2012-10-01)
Cimetidine, an H-2 receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing ...
Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
(Scientific Research, 2013-10-30)
Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, ...
Characterization and functionality of proliferative human sertoli cells
(Cognizant Communication Corp, 2011-05)
It has long been thought that mammalian Sertoli cells are terminally differentiated and nondividing postpuberty. For most previous in vitro studies immature rodent testes have been the source of Sertoli cells and these ...
Prenatal exposure to pesticides disrupts testicular histoarchitecture and alters testosterone levels in male Caiman latirostris
(Elsevier, 2009-07)
The increased use of agrochemical pesticides, such as atrazine (ATZ) and endosulfan (END), may have a significant impact on ecosystem health and biodiversity. The aim of this study was to investigate the consequences of ...
17 beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells
(Soc Study Reproduction, 2008-01-01)
The aim of the present study was to determine the mechanisms involved in estrogen actions in cultured rat Sertoli cells. RT-PCR detected transcripts for the estrogen receptors ESR1 and ESR2 in cultured immature Sertoli ...
Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats
(2012-10-01)
Cimetidine, an H2 receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing ...
Cimetidine-induced vascular cell apoptosis impairs testicular microvasculature in adult rats
(2012-10-01)
Cimetidine, an H2 receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing ...
Androgen insensitivity syndrome at prepuberty: Marked loss of spermatogonial cells at early childhood and presence of gonocytes up to puberty
(Karger, 2018-02)
Androgen insensitivity syndrome (AIS) is a hereditary condition in patients with a 46,XY karyotype in which loss-of-function mutations of the androgen receptor (AR) gene are responsible for defects in virilization. The aim ...
NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens
(Biomed Central Ltd, 2013-04-09)
Background: Cimetidine, histamine H-2 receptors antagonist, has caused adverse effects on the male hormones and reproductive tract due to its antiandrogenic effect. in the testes, peritubular myoid cells and muscle vascular ...