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Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response
(2016-05-01)
The orexins are hypothalamic neuropeptides involved in an array of functions such as regulation of sleep/wake states and chemoreception to CO2/pH. The locus coeruleus (LC) is a chemosensitive site and expresses an extensive ...
Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function, but not food intake, in the absence of full hypothalamic NPY-ergic activity
(Humana Press, 2005-12)
Neonatal monosodium L-glutamate (MSG) treatment destroys hypothalamic arcuate nucleus neuronal bodies, thus inducing several metabolic abnormalities. As a result, rats develop a phenotype characterized by hyperleptinemia ...
Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation
(2021-08-01)
The ability to distinguish between threatening (repulsors), neutral and appetitive stimuli (attractors) stimuli is essential for survival. The orexinergic neurons of hypothalamus send projections to the limbic structures, ...
The Evolutionary History of The Orexin/Allatotropin GPCR Family: From Placozoa and Cnidaria to Vertebrata
(Nature Research, 2019-07)
Peptidic messengers constitute a highly diversified group of intercellular messengers widely distributedin nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, itseem that they ...
Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model
(Public Library of Science, 2014-01)
Overconsumption of palatable energy-dense foods has negative health implications and it is associated with obesity andseveral eating disorders. Currently, little is known about the neuronal circuitries activated by the ...