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Neuroinflammation and glial cell activation in mental disorders
(Elsevier, 2020-02)
Mental disorders (MDs) are highly prevalent and potentially debilitating complex disorders which causes remain elusive. Looking into deeper aspects of etiology or pathophysiology underlying these diseases would be highly ...
Efeito da suplementação crônica com áxido graxo poliinsaturado ômega -3 e gordura vegetal hidrogenada em um modelo de comportamento doentio: influência da via da quinurenina nas alterações neurocomportamentaisEffect of chronic supplementation with omega -3 polyunsaturated fatty acid and hydrogenated vegetable fat in a model of unhealthy behavior: influence of the quinurenine pathway on neurobehavioral changes
(Universidade Federal do PampaUNIPAMPADoutorado em BioquímicaBrasilCampus Uruguaiana, 2021)
CAMBIO EN LA EXPRESIÓN DE LA ENZIMA KINURENINA AMINOTRANSFERASA II POR LA ADMINISTRACIÓN DE PROBENECID EN UN MODELO DE LA ENFERMEDAD DE HUNTINGTON
(2011-12-05)
Huntington disease (HD), a hereditary dominant autosomic sickness, is caused by an
overexpression of CAG repeats in the gene encoding the protein huntingtine (Htt).
HD is characterized by neurodegeneration in the striatum. ...
Metabolismo del triptófano en células dendríticas maduradas con cortos estímulos con lipopolisacárido
(Universidad de Chile, 2010)
Las células dendríticas (DCs) constituyen un grupo heterogéneo de células presentadoras de
antígenos profesionales que juegan un papel fundamental en la respuesta inmune innata y
adquirida. Éstas tienen el potencial de ...
Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications
(American Chemical Society, 2016-05)
Human indoleamine 2,3-dioxygenase catalyzes the oxidative cleavage of tryptophan to N-formyl kynurenine, the initial and rate-limiting step in the kynurenine pathway. Additionally, this enzyme has been identified as a ...
Evidence for a ferryl intermediate in a heme-based dioxygenase
(National Academy of Sciences, 2009-09)
In contrast to the wide spectrum of cytochrome P450 monooxygenases, there are only 2 heme-based dioxygenases in humans: tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). hTDO and hIDO catalyze the same ...
3-Hydroxykynurenine bound to eye lens proteins induces oxidative modifications in crystalline proteins through a type I photosensitizing mechanism
(Elsevier Inc., 2019)
Photosensitized reactions mediated by endogenous chromophores have been associated with the etiology of age-related cataract disease. Endogenous chromophores such as 3-hydroxykynurenine (3OHKN) can be found in both free ...
Avaliação dos metabólitos do triptofano e perfil de resposta imune na pele de cães com leishmaniose visceral
(Universidade Estadual Paulista (Unesp), 2022-05-03)
A Leishmaniose Visceral (LV) é uma antropozoonose causada pelo protozoário Leishmania infantum, cuja pele é o sítio inicial da infecção, antes da visceralização do parasita. Os efeitos imunopatológicos da resposta imune ...