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Desensitization to ANG II in guinea pig ileum depends on membrane repolarization: role of maxi-K+ channel
(Amer Physiological Soc, 1999-10-01)
Desensitization of ANG II tonic contractile response of the guinea pig ileum is related to membrane repolarization determined by Ca2+-activated K+ (maxi-K+) channel opening. ANG II-stimulated depolarized myocytes presented ...
Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
(Sage Publications, 2014-04)
Through their control of cell membrane potential, potassium (K(+)) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K(+) channels in human umbilical artery ...
Actin modifies Ca2+ block of epithelial Na+ channels in planar lipid bilayers
(BIOPHYSICAL SOCIETY, 2001-05)
The mechanism by which the cytoskeletal protein actin affects the conductance of amiloride-sensitive epithelial sodium channels (ENaC) was studied in planar lipid bilayers. In the presence of monomeric actin, we found a ...
Pore accessibility during C-type inactivation in Shaker K+ channels
(1998)
Shaker K+ channels inactivate through two distinct molecular mechanisms: N-type, which involves the N-terminal domain and C-type that appears to involve structural modifications at the external mouth of the channel. We ...
Effective pore size and radius of capture for K+ ions in K-channels
(NATURE PUBLISHING GROUP, 2016-02)
Reconciling protein functional data with crystal structure is arduous because rare conformations or crystallization artifacts occur. Here we present a tool to validate the dimensions of open pore structures of potassium-selective ...
Differential expression of potassium channels in placentas from normal and pathological pregnancies: Targeting of the K ir 2.1 channel to lipid rafts
(2012)
Potassium channels play important physiological roles in human syncytiotrophoblasts (hSTBs) from placenta, an epithelium responsible for maternal-fetal exchange. Basal and apical plasma membranes differ in their lipid and ...
Possible role of apamin‐sensitive K+ channels in myotonic dystrophy
(1994)
Myotonic muscular dystrophy is a genetic disease characterized mainly by muscle atrophy and myotonia, a repetitive electrical activity of muscle. In the present study, the possible role of apamin‐sensitive K+ channels in ...
Voltage-controlled gating in a large conductance Ca2+-sensitive K+ channel (hslo)
(National Academy of Sciences, 1997)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage-and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged residues ...
External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle
(2003)
We have characterized the effect of external
copper on the gating properties of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle, incorporated into artificial
bilayers. The ...