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Chitin-Like Molecules Associate with Cryptococcus neoformans Glucuronoxylomannan To Form a Glycan Complex with Previously Unknown Properties
(Amer Soc Microbiology, 2012-09-01)
In prior studies, we demonstrated that glucuronoxylomannan (GXM), the major capsular polysaccharide of the fungal pathogen Cryptococcus neoformans, interacts with chitin oligomers at the cell wall-capsule interface. the ...
Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin
(National Academy of Sciences, 2020-02)
Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), ...
Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments
(Wiley, 2009-06)
The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful ...
Melanocyte transformation associated with substrate adhesion impediment
(Neoplasia Press, 2006-03-01)
Exclude experimental models of malignant transformationemploy chemical and physical carcinogens or genetic manipulations to study tumor progression. in this work, different melanoma cell lines were established after ...
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome
(American Society for Biochemistry and Molecular Biology, 2020)
The importance of the microbiome in health and its disruption in disease is continuing to be elucidated. However, the multitude of host and environmental factors that influence the microbiome are still largely unknown. ...
Anti-glycan antibodies halt axon regeneration in a model of Guillain Barrè Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2
(Academic Press Inc Elsevier Science, 2016-04)
Several reports have linked the presence of high titers of anti-Gg Abs with delayed recovery/poor prognosis in GBS. In most cases, failure to recover is associated with halted/deficient axon regeneration. Previous work ...
Muc1 and glycan expression in the oviduct and endometrium of a new world monkey, Cebus apella
(OXFORD UNIV PRESS INC, 2001)
Cebus apella is a New World monkey that has a menstrual cycle of 18-23 days with implantation at approximately luteal Day 5, The aim of this study was to characterize by lectin- and antibody-labeling the distribution of ...
Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response
(Scion Publishing Ltd, 2007)
Protein-glycan interactions mediate a variety of biological processes including cell trafficking, activation, differentiation, and survival. Galectins, a growing family of animal lectins defined by shared consensus amino ...
N-glycome profiling of Bothrops jararaca newborn and adult venoms
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Glycosylation is an important post-translational modification of snake venom proteins and contributes to venom proteome complexity. Many snake venom components are known to be glycosylated, however, very little is known ...