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Imunogenicidade de proteínas recombinantes da superfície do merozoíta de Plasmodium vivax candidatas à vacina contra malária.
(Universidade Federal de São Paulo (UNIFESP), 2006-01-01)
The aim of this study was to evaluate in a murine model, the capacity of the helper epitope PADRE (Pan Allelic DR epitope) to improve the immunizations with the P. vivax MSP119 in the presence of distinct adjuvant formulations. ...
A recombinant vaccine based on domain II of Plasmodium vivax Apical Membrane Antigen 1 induces high antibody titres in mice
(ELSEVIER SCI LTD, 2010)
The Apical Membrane Antigen 1 (AMA-1) is considered a promising candidate for development of a malaria vaccine against asexual stages of Plasmodium. We recently identified domain II (DII) of Plasmodium vivax AMA-1 (PvAMA-1) ...
Evaluation of the Efficacy of Outer Membrane Protein 31 Vaccine Formulations for Protection against Brucella canis in BALB/c Mice
(American Society for Microbiology, 2014-10)
Canine brucellosis is an infectious disease caused by the Gram-negative bacterium Brucella canis. Unlike conventional control programs for other species of the genus Brucella, currently there is no vaccine available against ...
Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection
(American Society for Microbiology, 2009-01)
Available vaccines against Brucella spp. are live attenuated Brucella strains. In order to engineer a better vaccine to be used in animals and humans, our laboratory aims to develop an innocuous subunit vaccine. Particularly, ...
Resistance to experimental autoimmune encephalomyelitis development in Lewis rats from a conventional animal facility
(Instituto Oswaldo Cruz, Ministério da Saúde, 2007-12-01)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the brain and spinal cord that is mediated by CD4+ T lymphocytes specific to myelin components. In this study we compared development of EAE in ...
Assessment of neutralizing capacity of antibodies raised in mice against a Crotalus durissus terrificus phosphodiesterase
(Fundación Revista Medicina, 2019)
Phosphodiesterases (PDE) belong to a super-family of enzymes that have multiple roles in the metabolism of nucleotides. These enzyme classes have played such a critical role as tools in the field of molecular biology, but ...