Buscar
Mostrando ítems 21-30 de 140
Inhibition Of IGF1R by IGF-1R/IR Inhibitor OSI906 as a Targeted Therapy for Glioblastoma: In Vitro & in Vivo Studies
(Karger, 2019)
Background: CNS tumors are the most frequent solid tumors in children. In paediatric gliomas, IGF-1R nuclear localization was significantly associated with both high grade tumours and increased risk of death and contributed ...
NAD(P)H-oxidase presence in Toxoplasma gondii tachyzoite vacuole during interaction with IFN-gamma-activated human endothelial cells
(American Society of Parasitologists, 2019)
High Iodine Concentration Attenuates RET/PTC3 Oncogene Activation in Thyroid Follicular Cells
(MARY ANN LIEBERT INC, 2009)
Background: Papillary thyroid carcinoma (PTC) is frequently associated with a RET gene rearrangement that generates a RET/PTC oncogene. RET/PTC is a fusion of the tyrosine kinase domain of RET to the 50 portion of a different ...
Cortical granule exocytosis is mediated by alpha-SNAP and N-Ethilmaleimide sensitive factor in mouse eggs
(Public Library of Science, 2015-08-12)
Cortical granule exocytosis (CGE), also known as cortical reaction, is a calciumregulated secretion that represents a membrane fusion process during meiotic cell division of eggs. The molecular mechanism of membrane fusion ...
Discovery of a Potent and Selective Chikungunya Virus Envelope Protein Inhibitor through Computer-Aided Drug Design
(American Chemical Society Inc, 2021-05)
The worldwide expansion of chikungunya virus (CHIKV) into tropical and subtropical areas in the last 15 years has posed a currently unmet need for vaccines and therapeutics. The E2-E1 envelope glycoprotein complex binds ...
Estudo da atividade biológica do motivo ECD do domínio tipo-desintegrina da botropasina
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-05-10)
Integrins are cell surface receptors that mediate cell adhesion and platelet aggregation, although they do part of important physiological processes in the organism, are also related pathologies such as tumorigenesis, ...
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1
(Pergamon-elsevier Science Ltd, 2012-10-17)
We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av ...
DISTRIBUCIÓN INTRACELULAR DE LA PROTEASA VIRAL 3CD DEL FCV DURANTE LA INFECCIÓN
(2011-06-06)
Acute gastroenteritis is an important health problem with high mobility and mortality rates in the entire world. It is caused by several pathogens, such as viruses. Among them, the members of the Caliciviridae family, that ...
Evaluation of the potential teratogenic and toxic effect of the herbicide 2,4-D (DMA (R) 806) in bullfrog embryos and tadpoles (Lithobates catesbeianus)
(Elsevier B.V., 2021-03-01)
The objective of this work was to evaluate the potential teratogenic and toxic effect of the herbicide 2,4-D (DMA (R) 806) on bullfrog embryos and tadpoles (Lithobates catesbeianus). We used the FETAX (Frog Embryo Teratogenesis ...