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Magnesium interactions with a CX26 connexon in lipid bilayers
(Springer Verlag Berlín, 2019-07-20)
Following our previous work, where we described the interaction of calcium with the Cx26 hemichannel, we further explore the same system by atomistic molecular dynamics simulations considering a different di-cation, ...
Connexin and pannexin-based channels in oligodendrocytes: Implications in brain health and disease
(Frontiers Media S.A., 2019)
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis
(Springer, 2016)
Skeletal muscles of patients with Duchenne muscular dystrophy (DMD) show numerous alterations including inflammation, apoptosis, and necrosis of myofibers. However, the molecular mechanism that explains these changes remains ...
A novel missense mutation p.L76P in the GJB2 gene causing nonsyndromic recessive deafness in a Brazilian family
(Associação Brasileira de Divulgação Científica, 2009)
Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of nonsyndromic recessive hearing loss in many countries. We report here on a novel point mutation in GJB2, p.L76P (c.227C>T), in compound ...
Role of connexin 26 hemichannels in the regulatión of purinergic calcium signaling under physiólogical and pathological conditións
(2013)
Gap junction channels (GJCs) are intercellular channels that connect the cytoplasm of two neighboring cells. They allow the exchange of cytoplasmic molecules up to about 1 kD, including metabolites, second messengers and ...
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
(2018)
The classical view of synapses as the functional contact between presynaptic and
postsynaptic neurons has been challenged in recent years by the emerging regulatory
role of glial cells. Astrocytes, traditionally considered ...
Epidemias no ensino de ciências: contribuições a partir de uma compreensão crítica
(Universidade Federal de São CarlosUFSCarCâmpus SorocabaCiências Biológicas - CBL-So, 2021-06-23)
In late 2019, an outbreak of a new disease called COVID-19 occurred in China. In a few weeks, the virus had spread to several continents and set off a pandemic. Faced with this new obstacle, with a growing number of deaths, ...