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In vitro study of the cytotoxic and genotoxic effects of indomethacin-loaded Eudragit (R) L 100 nanocapsules
(Funpec-editora, 2016-01-01)
Indomethacin is a non-steroidal anti-inflammatory agent included in one of the most commonly used drug classes worldwide. The use of this drug results in certain side effects, including gastrointestinal complications. ...
Avaliação toxicogenética e atividade antitumoral in vitro de complexos heterolépticos de Rutênio(II): Atividades citotóxicas, genotóxicas e interação com biomoléculas
(Universidade Estadual Paulista (Unesp), 2016-03-24)
Os ensaios de toxicologia genética são utilizados como base no desenvolvimento de novos fármacos, uma vez que podem identificar rapidamente agentes que causam danos ao material genético. Agências regulatórias preconizam a ...
In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2019)
Avaliação da segurança in vitro de nanotubos de carbono de paredes múltiplas funcionalizados com polietilenoglicol em linhagem de fibroblasto de pulmão de hamster (V79-4)
(Universidade Federal de Minas GeraisUFMG, 2018-06-15)
Carbon nanotubes (CNT) comprise an important class of materials with excellent physicochemical properties, which have received great attention in biological applications. Conflicting data regarding their cytotoxic effects ...
A combination of the cytokinesis-block micronucleus cytome assay and centromeric identification for evaluation of the genotoxicity of dicamba
(Elsevier Ireland, 2011-12)
The purpose of this study was to further investigate the cytotoxic and genotoxic effects of dicamba and Banvel® employing the cytokinesis-block micronucleus cytome (CBMN-cyt) assay estimated by the analysis of the nuclear ...
Avaliação da genotoxicidade e do potencial osteogênico de polissacarídeos sulfatados de algas marinhas
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2017-05-26)
Problems related with bone defects continue to motivate the search for more effective therapies. Thus, the combination of biomaterials, stem cells and bioactive molecules is part of the tools used by regenerative medicine ...
Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssoptfolia L. on HepG2 cells
(Elsevier B.V., 2015-07-21)
Ethnopharmacological relevance: Euphorbia hyssopifolia L. is a weed with recognized antimicrobial potential employed in Indian, Asian and Latin-American popular medicine. However, little is known with regard to its toxic ...
Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression
(Taylor & Francis Ltd, 2017-07-25)
Context: Indigofera suffruticosa Miller (Fabaceae) and I. truxillensis Kunth produce compounds, such as isatin (ISA) and indirubin (IRN), which possess antitumour properties. Their effects in mammalian cells are still not ...