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Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology
(Karger, 2010)
Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles in numerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normal and tumoral anterior ...
Prolactin induces apoptosis of lactotropes in female rodents
(Public Library Of Science, 2014-05)
Anterior pituitary cell turnover occurring during female sexual cycle is a poorly understood process that involves complex regulation of cell proliferation and apoptosis by multiple hormones. In rats, the prolactin (PRL) ...
Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation
(Springer Netherlands, 2017-12)
Humanin (HN) and Rattin (HNr), its homologous in the rat, are peptides with cytoprotective action in several cell types such as neurons, lymphocytes and testicular germ cells. Previously, we have shown that HNr is expressed ...
Cadmium mimics estrogen-driven cell proliferation and prolactin secretion from anterior pituitary cells
(Public Library of Science, 2013-11-13)
Cadmium (Cd) is a heavy metal of considerable occupational and environmental concern affecting wildlife and human health. Recent studies indicate that Cd, like other heavy metals, can mimic effects of 17β-estradiol (E2) ...
Cellular and molecular specificity of pituitary gland physiology
(American Physiological Society, 2012-01)
The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their integration are mediated by cell interactions and cross-talk of ...
Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression
(American Physiological Society, 2012-01)
Since anterior pituitary expresses prolactin receptors, prolactin secreted by lactotropes could exert autocrine or paracrine actions on anterior pituitary cells. In fact, it has been observed that prolactin inhibits its ...
Pituitary tumors: Cell type-specific roles for BMP-4
(Elsevier Ireland, 2010-09)
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and ...
Effect of ionotropic and metabotropic glutamate agonists and D-aspartate on prolactin release from anterior pituitary cells
(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2002-03)
Although the presence of ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptors has been demonstrated in the anterior pituitary, recent reports on the direct effect of glutamate on prolactin (PRL) secretion by ...
Gender differences in the expression of galanin and vasoactive intestinal peptide in oestrogen-induced prolactinomas of Fischer 344 rats
(Cell Press, 2004)
We have previously described a sexual dimorphism in oestrogen-induced anterior pituitary tumorigenesis in Fischer 344 rats, with female tumours averaging twice the size of those of males. Neonatal androgenization of female ...