Buscar
Mostrando ítems 21-30 de 861
Human apolipoprotein A-I binds amyloid-beta and prevents A beta-induced neurotoxicity
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Aggregates of the amyloid-P peptide (A beta) play a central role in the pathogenesis of Alzheimer`s disease (AD). Identification of proteins that physiologically bind A beta and modulate its aggregation and neurotoxicity ...
Estimation of electrokinetic and hydrodynamic global properties of relevant amyloid-beta peptides through the modeling of their effective electrophoretic mobilities and analysis of their propensities to aggregation
(Wiley VCH Verlag, 2014-07)
Neuronal activity loss may be due to toxicity caused by amyloid-beta peptides forming soluble oligomers. Here amyloid-beta peptides (1–42, 1–40, 1–39, 1–38, and 1–37) are characterized through the modeling of their ...
Global properties and propensity to dimerization of the amyloid-beta (12-28) peptide fragment through the modeling of its monomer and dimer diffusion coefficients and electrophoretic mobilities
(Wiley, 2015-03)
Neuronal activity loss may be due to toxicity caused mainly by amyloid-beta (1–40) and (1–42) peptides forming soluble oligomers. Here the amyloid-beta (12–28) peptide fragment (monomer) and its dimer are characterized at ...
Gold Nanoparticles Mediate Improved Detection of beta-amyloid Aggregates by Fluorescence
(MDPI, 2020)
The early detection of the amyloid beta peptide aggregates involved in Alzheimer's disease is crucial to test new potential treatments. In this research, we improved the detection of amyloid beta peptide aggregates in vitro ...
A deposição de peptídeo beta-amiloide e as alterações vasculares presentes na doença de AlzheimerThe deposition of amyloid-beta peptide and the vascular lesions in Alzheimer's disease
(Journal of Health & Biological Sciences, 2016)
Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005)
The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar beta-amyloid (A beta) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules ...
In silico evidence of direct interaction between statins and β-amyloid
(Wiley-Liss Inc., 2019)
Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology
(Hindawi Publishing Corporation, 2018-01-31)
Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's, Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of brain aging is highly reactive with water and oxygen ...