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The Role of Lipotoxicity in Smoke Cardiomyopathy
(Public Library Science, 2014-12-02)
Background/Aims: Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known.Methods: ...
Allosteric Pathways In The Pparγ 3-rxrα Nuclear Receptor Complex
(Nature Publishing Group, 2016)
Hypothalamic Actions of Tumor Necrosis Factor alpha Provide the Thermogenic Core for the Wastage Syndrome in Cachexia
(ENDOCRINE SOC, 2010)
TNF alpha is an important mediator of catabolism in cachexia. Most of its effects have been characterized in peripheral tissues, such as skeletal muscle and fat. However, by acting directly in the hypothalamus, TNF alpha ...
Antiobesity Effects of yerba mate Extract (Ilex paraguariensis) in High-fat Diet-induced Obese Mice
(NATURE PUBLISHING GROUP, 2009)
Because the potential of yerba mate (Ilex paraguariensis) has been suggested in the management of obesity, the aim of the present study was to evaluate the effects of yerba mate extract on weight loss, obesity-related ...
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
(2016)
Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as "excitation-transcription" (E-T) coupling. We have demonstrated that release of adenosine 5'-triphosphate (ATP) during ...